UNLABELLED The aim of the study was to investigate the gender differences in patients with schizophrenia in age of onset, other demographic and clinical characteristics and their relationship with QEEG power spectrum measures. MATERIAL AND METHODS Thirty patients with schizophrenia were enrolled in the study, 17 female and 13 male, mean age 34 years. Comprehensive assessment of the symptoms o...

UNLABELLED We compared a set of surface EMG (sEMG) parameters in several groups of schizophrenia (SZ, n = 74) patients and healthy controls (n = 11) and coupled them with the clinical data. sEMG records were quantified with spectral, mutual information (MI) based and recurrence quantification analysis (RQA) parameters, and with approximate and sample entropies (ApEn and SampEn). Psychotic deter...

PALMFlexS, a prospective multicentre, open-label, 6-month, phase IIIb interventional study, explored tolerability, safety and treatment response in adults (n = 231) with non-acute but symptomatic schizophrenia switching to flexibly dosed paliperidone palmitate (PP) after unsuccessful treatment with risperidone long-acting injectable therapy (RLAT) or conventional depot antipsychotics (APs). Tre...

Introduction Network analysis has been used to explore the interplay between psychopathology and functioning in psychosis, but no study dedicated statistical techniques focus on bridge symptoms connecting these domains. Objectives The current aims estimate network of depressive, negative, positive symptoms, general psychopathology, real-world people with first-episode schizophrenia or schizophr...

BACKGROUND Abnormality in the concentration and functioning of gamma-aminobutyric acid (γ-aminobutyric acid, GABA) in the brain is not only an important hypothetical link to the cause of schizophrenia but it may also be correlated with the cognitive decline and negative symptoms of schizophrenia. Studies utilizing high field magnetic resonance spectroscopy (MRS) report abnormal density of GABA ...

BACKGROUND The co-morbid occurrence of anxiety disorders and schizophrenia has recently begun to be investigated. Social anxiety may be especially important to diagnose and manage among patients with schizophrenia. AIM To investigate the prevalence and correlates of social phobia in patients with schizophrenia. METHOD Diagnosis of schizophrenia and schizoaffective disorders as well as co-mo...

BACKGROUND To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describes the usefulness of a drug therapy was calculated using the efficacy of the ...

Patients 201 patients >18 years of age (mean age 40 y, 53% men) who had bipolar disorder, mania, or a mixed diagnosis confirmed with the Structured Clinical Interview for DSMIII-R considered by the site physician to have severe agitation requiring injections and who had a total score >14 on the 5 item Positive and Negative Syndrome Scale-Excited Component (PANSS-EC) scale with >1 individual sco...

BACKGROUND Alternative and traditional healing methods are common and popular in Sudan, particularly for treating people with mental disorders, but little information is available about the outcome of theses traditional healing approaches. OBJECTIVES To study the outcome of treating patients with psychotic disorders by traditional healers, and to understand the type of services, interventions...

AIM The aim of the present study was twofold: 1. to compare the efficacy of three antipsychotics (ziprasidone, olanzapine and perazine) in schizophrenia 2. to compare the improvement in cognitive functioning between groups treated with the three different neuroleptics. METHOD A total of 58 Caucasian patients diagnosed with paranoid schizophrenia were recruited into the study group. We used th...