At late fetal age (21.5 days postcoitum [dpc]), GK rats present a severely reduced beta-cell mass compared with Wistar rats. This anomaly largely antedates the onset of hyperglycemia in GK rats. Thus, the beta-cell mass deficit could represent the primary defect leading to type 2 diabetes in the adult. The aim of this work was to investigate, in GK fetuses at the end of fetal age (21.5 dpc), wh...

autosomal dominant polycystic kidney disease (adpkd) is an inherited disorder associated with multiple cyst formation in the different organs. development of pancreatic cyst in adpkd is often asymptomatic and is associated with no complication. a 38‑year‑old man with adpkd was presented with six episodes of acute pancreatitis and two episodes of cholangitis in a period of 12 months. various ima...

background : pancreatic cancer is a major worldwide health problem. little is known about the etiology of pancreatic cancer, which is an important cause of cancer mortality in developed countries. this study evaluates the importance of amounts of trace elements in pancreatic cancer etiology and diagnostics. methods : atomic absorption spectrometry was used to estimate zinc, selenium, copper, ca...

in order to obtain maximum information from magnetic and gravity anomaly maps, application of an edgedetection method is necessary. in this regard two commonly used methods are derivative filters and local phase filters. in this paper, a matlab code is expanded to combine an analytic signal filter and a tilt angle filter as a new edge detection filter called asta filter. this method was demonst...

background pancreatic cancer (pc) is classified as one of the most deadly cancers. since the role of diet in modifying the effects of known risk factors of pc has been well established, exploring the dietary intakes in relation to the etiology of pc can be useful for elucidating the mechanisms of the disease progression. methods and materials this study was conducted within the golestan prospec...

background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing.   methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...

Background: Optimized RNA extraction from tissues and cell lines consists of four main stages regardless of the method of extraction: 1) homogenizing, 2) effective denaturation of proteins from RNA, 3) inactivation of ribonuclease, and 4) removal of any DNA, protein, and carbohydrate contamination. Isolation of undamaged intact RNA is challenging when the related tissue contains high levels of ...

Diabetes is a chronic disease characterized by decrease in pancreatic insulin production. The immune system will be harmed due to this condition, which raise blood sugar levels. However, early detection of diabetes enables patients begin treatment on time, therefore reducing or eliminating the risk severe consequences. One most significant challenges healthcare unit diagnosis. Traditional techn...