Objective The sensitivity of pancreatic juice cytology for intraductal papillary mucinous neoplasm is insufficient. We evaluated the usefulness of repeated pancreatic juice cytology via an endoscopic naso-pancreatic drainage tube combined with carcinoembryonic antigen level of pancreatic juice for the diagnosis of malignant intraductal papillary mucinous neoplasm. Methods Between April 2004 and...

Pancreatic tuberculosis is a rare condition but as a result of increasing migration, tuberculosis is expanding internationally. We present a case of pancreatic tuberculosis in a 25 years old woman who presented with fever, and epigastric mass with pain. CT scan finding was compatible with pancreatic abscess, laparoscopic finding showed caseous materials. Granuloma was found in histology of panc...

There is eternal discussion on the best surgical method of pancreatoduodenectomy and reconstruction method. Several different methods of pancreatic stump anastomosis exist. The most popular argument taken into account in the discussion is the frequency of early postoperative complications. Relatively fewer papers analyse the late functional outcome of pancreatic surgery and the method of anasto...

Exocrine pancreatic function was studied in 14 inpatients with newly diagnosed maturity onset diabetes mellitus. Five patients had clinical and biochemical evidence of pancreatic disease (two carcinoma, three pancreatitis). The other nine patients had no clinical pancreatic disease but all except one had at least one abnormal result of pancreatic function tests. None of this group with idiopath...

BACKGROUND Internal pancreatic fistula (IPF) is a well-recognized complication of pancreatic diseases. Although there have been many reports concerning IPF, the therapy for IPF still remains controversial. We herein report our experiences with endoscopic transpapillary pancreatic stent therapy for IPF and evaluate its validity. METHOD Six patients with IPF who presented at our department and ...

Recent microarray analyses showed that the S100 family contains members that are candidate diagnostic markers or therapeutic targets. In the present study, to evaluate the involvement of S100A6 in pancreatic cancer and its clinical usefulness for diagnosis, we examined S100A6 mRNA expression in pancreatic tissues and pancreatic juice from patients with different pancreatic diseases. To investig...

PURPOSE The targeting protein for Xklp2 (TPX2) has recently gained attention as a putative oncogene possibly amplified in several human malignancies, including pancreatic adenocarcinoma. In this work, we sought to evaluate the copy number and expression of TPX2 in pancreatic cancer cell lines and tumor tissues and to further explore the potential of TPX2 as a therapeutic target. EXPERIMENTAL ...

A 57-year-old man underwent endoscopic retrograde cholangiopancreatography (ERCP) for multiple bile duct and gallbladder stones. During the ERCP, we attempted to insert a prophylactic 5-Fr, single pigtail pancreatic stent (Cook Endoscopy, Winston-Salem, North Carolina, United States) because biliary cannulation is difficult and the pancreatic duct is frequently cannulated unintentionally; howev...

Insulin secretion from pancreatic β cells has an important role in the onset of type 2 diabetes. Insulin secretion from pancreatic β cells is regulated by pancreatic β cell mass and their insulin secretory function. By using pancreatic β cell-specific Rac1-knockout mice, we recently showed that Rac1 deletion, even with no reduction in pancreatic β cell mass, inhibits F-actin depolymerization, w...

Pancreatic cancer belongs to the most aggressive cancer types, with an incidence rate equallig mortality rate. It is well‐known that type 2 diabetes is a significant risk factor for pancreatic cancer. Interestingly, several studies have shown that pancreatic cancer can also lead to type 2 diabetes, as part of the pancreatic cancer induced paraneoplastic syndrome. Multiple factors have been prop...