A new catalytic approach for the synthesis of substituted quinolines via C-N and C-C bond formation using 2-haloaryl hydroxylamines and allylic C-H substrates is described. Fe-catalyzed allylic C-H amination followed by Pd-catalyzed intramolecular Heck-coupling and aerobic dehydrogenation deliver the valuable quinoline and naphthyridine heterocycles in good to excellent overall yields. In this ...

The direct synthesis of N-arylated carbazoles through a palladium-catalyzed amination of cyclic iodonium salts with anilines is described. In particular, electron-poor aniline derivatives reacted smoothly with only 5 mol % of Pd(OAc)2 as catalyst to give the desired products in up to 71% yield. Furthermore, the reactivity of cyclic iodonium salts is compared with the reactivity of the correspon...

A facile and less expensive monophosphinite ligand 2-(diphenylphosphinoxy)-naphthyl, C H OPPh (1) has been synthesized from the reaction 10 7 2 f -naphthol with chlorodiphenylphosphine. The mixture of Pd(OAc)2 and 1 catalyzes the Suzuki cross-coupling of a variety of aryl halides with ryl boronic acids at room temperature or at 60 ◦C, giving generally high yields even under low catalytic loads....

Pd nanoparticles with different sizes and diameter distributions were successfully deposited on the surface of disordered mesoporous carbon spheres (DMHCS). The size and diameter distribution of the Pd particles were controlled by the application of different experimental conditions. Two methods of synthesis (reflux and impregnation) and two Pd precursors (palladium (II) acetyloacetonate (Pd(ac...

The mechanism for direct insertion of O(2) in a toluene-solvated palladium-hydride bond (avoiding palladium zero) has been elucidated using quantum mechanics (B3LYP/LACVP** with the PBF polarizable continuum solvent model) for Pd(II)(-)-sparteine)(Cl)(H) and the model compound Pd(II)(bipyridine)(Cl)(H). We find that the process involves (1) the abstraction of the hydrogen atom by triplet oxygen...

a powerful and convenient reaction procedure for the c-n coupling reaction (the buchwald-hartwig reaction), yielding products of n-arylanilines and n-arylamines in both conventional heating and microwave irradiation has been reported. the protocol utilizes a stable and new supper ferromagnetic nanoparticle chelating n-heterocyclic dicarbene palladium(ii) complex (pd-nhc) as catalyst which helps...

1,2,3-Ferrocenyl triazole ligands generated by click reactions in dendrimers bind Pd(OAc)2 with a systematic one-to-one stoichiometry as monitored by titration using the ferrocenyl redox sensor attached to the triazole ring, and the dendritic PdII complexes formed are best reduced by methanol to form palladium nanoparticles of designed types and sizes that show excellent efficiency and selectiv...

A novel palladium-catalyzed intermolecular aminopalladation/C-H activation method for selectively synthesizing (E)-(2-oxindolin-3-ylidene)phthalimides has been developed. In the presence of Pd(OAc)2 and PhI(OAc)2, alkynes were difunctionalized with a phthalimide and an arene sp2 C-H bond to selectively synthesize (E)-(2-oxoindolin-3-ylidene)phthalimides, which products are of great potential ph...

Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct C2-arylation of benzothiophene derivatives under low catalyst concentration. The reaction can be performed employing as little as 0.5-0.1 mol-% catalyst with electron-deficient and some electron-rich aryl bromides. The presence of a methyl or a formyl substituent at C3 of benzothiophene has a minor influence on the reactivit...

We report a new synthesis of phenanthridines based on palladium-catalyzed picolinamide-directed sequential C-H functionalization reactions starting from readily available benzylamine and aryl iodide precursors. Under the catalysis of Pd(OAc)2, the ortho-C-H bond of benzylpicolinamides is first arylated with an aryl iodide. The resulting biaryl compound is then subjected to palladium-catalyzed p...