Painful diabetic neuropathy are common and present a major challenge to the practicing physician. Pain is universal symptom in patients with rare acute sensory neuropathy and is present in only upto 50% of those patients with the common chronic sensory motor neuropathy. The first step in symptom management is to stabilize glycemic control. There is increasing evidence that blood glucose flux ma...

objective(s):painful diabetic neuropathy is associated with hyperexcitability and hyperactivity of spinal cord neurons. however, its underlying pathophysiological mechanisms have not been fully clarified. induction of excitatory/inhibitory neurotransmission imbalance at the spinal cord seems to account for the abnormal neuronal activity in diabetes. protective properties of neurosteroids have b...

OBJECTIVE Magnetic resonance spectroscopy (MRS) (specifically, (1)H-MRS) has been used to show changes in the brain following peripheral nerve injury in subjects without diabetes. This study used (1)H-MRS to examine the brain in subjects with or without painful diabetic neuropathy. RESEARCH DESIGN AND METHODS Twenty-six diabetic subjects (12 with and 14 without chronic neuropathic pain) were ...