it was shown that permethrin resistance in adult anopheles stephensi is due to at least three separate mechanisms. cytochrome p-450s and esterases are responsible for two-thirds of the 8-fold enhanced tolerance of the dub-apr resistant strain as compared with a sensitive strain, ind-s. it was postulated that target site insensitivity is also involved. to test this hypothesis, we conducted a neu...

Congenital insensitivity to pain (CIP) is a rare autosomal recessive genetic disease caused by mutations in the SCN9A gene. We report a patient with the clinical features consistent with CIP in whom we detected a novel homozygous G2755T mutation in exon 15 of this gene. Routine electrophysiological studies are typically normal in patients with CIP. In our patient, these studies were abnormal an...

There has been tremendous progress in the detection and diagnosis of hereditary neuropathies and while the genes responsible for these rare neuropathies have improved our understanding of the development of the sensory system, they remain clinical enigmas with rare occurrences and diverse presentations. In 1963, Swanson first described two brothers with congenital insensitivity to pain, anhidro...

Predicting continued problematic levels of drinking after the early 20's could help with early identification of persons at risk. This study investigated whether hangover insensitivity could predict postcollege drinking and problems beyond the variance due to drinking patterns. In a preliminary study, 134 college seniors from a laboratory study of hangover (Time 1) were contacted and assessed 1...

Background Pain or fears about future pain is one of the main reasons for medical consultation. Patients and families use to believe that Cobb angle and back pain are linearly related. The relationship between scoliosis magnitude, HRQL and Self Perception of Trunk Deformity is not clear. To better understand this, a prospective data collection including age, main thoracic and lumbar or thoracol...