Numerous studies have shown associations between genetic variants and neuropathic pain disorders. Rare monogenic disorders are caused by mutations of substantial effect size in a single gene, whereas common disorders are likely to have a contribution from multiple genetic variants of mild effect size, representing different biological pathways. In this review, we survey the reported genetic con...

OBJECTIVE--To review a series of conceptual and methodological problems encountered in surveys primarily devoted to pain disorders. CRITERIA FOR INCLUSION AND EXCLUSION OF ARTICLES--Published reports were systematically collected by electronic database searches (Medline), citations in existing publications, and through personal contacts. Relevant articles from clinical and epidemiological resea...

UNLABELLED Temporomandibular disorders are a set of musculoskeletal dysfunctions within the masticatory system, with multiple etiologies. OBJECTIVE Since craniocervical dystonia can involve the same neuromuscular structure as the temporomandibular joint, we sought to assess the correlation between temporomandibular disorders and craniocervical dystonia. METHOD We applied the Research Diagno...

Objective: Determine the prevalence of accessory muscles around ankle patients with pain using magnetic resonance imaging (MRI) and evaluate its correlation other foot disorders. In addition, better understand association muscle types pain, mechanical due to compression forces structures or neuropathic mass effect tarsal tunnel. Methods: The MRIs obtained from 2007 2017 were retrospectively stu...

Mendelian heritable pain disorders have provided insights into human pain mechanisms and suggested new analgesic drug targets. Interestingly, many of the heritable monogenic pain disorders have been mapped to mutations in genes encoding ion channels. Studies in transgenic mice have also implicated many ion channels in damage sensing and pain modulation. It seems likely that aberrant peripheral ...

Background and aims: Fat degeneration in the multifidus muscle (Mm) was more common than other trunk muscles. We hypothesised that lipid contents of Mm patient-reported quality life (QOL) are related. However, there no papers examining association between fatty QOL using magnetic resonance spectroscopy (MRS). This cross-sectional study aimed to investigate QOL, evaluated with Japanese Orthopaed...

Primary pain disorders (formerly "functional pain syndromes") are common, under-diagnosed and under-treated in children and teenagers. This manuscript reviews key aspects which support understanding the development of pediatric chronic pain, points to the current pediatric chronic pain terminology, addresses effective treatment strategies, and discusses the evidence-based use of pharmacology. C...

Body image represents a multidimensional concept including body image evaluation and perception of body appearance. Disturbances of body image perception are considered to be one of the central aspects of anorexia nervosa and bulimia nervosa. There is growing evidence that body image distortion can be associated with changes in pain perception. The aim of our study was to examine the associatio...

background : the purpose of this study was to determine reliability and construct validity of a persian version of the gastrointestinal symptoms rating scale (gsrs) in 2 samples of patients with functional gastrointestinal disorders (fgid) and healthy persons. materials and methods : the clinical sample consisted of 143 patients diagnosed with fgid who were referred to the psychosomatic disorde...

AIM To describe the annual consultation prevalence of different patellofemoral disorders across the adult life span. BACKGROUND The knee is the second most common site for musculoskeletal pain. Evidence from sports injury and orthopaedic settings suggests that patellofemoral disorders constitute a significant proportion of knee pain cases, but we have no evidence from general practice - the s...