BACKGROUND Major surgical procedures, such as gastrectomy, result in extensive postoperative pain, which can lead to increased morbidity, discomfort and dissatisfaction among the patients. OBJECTIVES The aim of this study was to evaluate the effect of adding diclofenac suppositories or intravenous paracetamol, on morphine consumption and on the quality of postgastrectomy pain control. PATIE...

OBJECTIVE Crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. MATERIALS AND METHODS Subcutaneous injection of a diluted formal...

NSAIDs are anti-inflammatory, analgesic, and antipyretic agents, and they are typically used chronically to reduce pain, decrease stiffness, and improve function in patients with osteoarthritis, rheumatoid arthritis, and other forms of arthritis. Additionally, NSAIDs are also used for the more acute treatment of pain including headache, dysmenorrhea, and postoperative pain. However, NSAID use c...

Objectives: To evaluate the effect of pre operatively administered Diclofenac potassium, on the postoperative management of pain following removal of impacted lower third molars. Material and Methods: The study was carried out in the Department of Oral and Maxillofacial Surgery, Khyber College of Dentistry, Peshawar, from Jan 2009 to June 2009. Fifty patients were recruited in this study who we...

OBJECTIVE To compare the upper gastrointestinal (UGI) tolerability of celecoxib (a cyclooxygenase-2 specific inhibitor) and diclofenac using data from three randomised, double-blind clinical trials in osteoarthritis (OA) and rheumatoid arthritis (RA). METHODS Patients in two OA studies received either celecoxib 100 mg BID (n = 545), diclofenac 50 mg BID or TID (n = 540), or placebo (n = 200) ...

Objectives: The treatment of pain after surgery is central to the care of postoperative patients. Non-steroidal anti-inflammatory drugs are devoid of side effects of opioids like respiratory depression, vomiting, cardiac depression etc. Ketoprofen, a nonsteroidal anti-inflammatory drug, being in use since 1974, is not a much-studied drug. We decided to compare Ketoprofen and Diclofenac sodium f...

To compare the difference in pain score during flexible TRIAL DESIGN: cystoscopy between patients undergoing the procedure with plain lubricating gel only and plain gel with diclofenac suppository in a randomized control trial. : A total of 60 male patients with an indication of flexible cystoscopy METHODS were enrolled in a prospective, randomized controlled study. Patients were randomized i...

Intramuscular (IM) diclofenac rarely causes scarring (reported incidence <0.05%). Some patients attending the Pain Clinic at Universitas Academic Hospital, Bloemfontein, South Africa, presented with scars that had developed after IM diclofenac injections. We investigated the prevalence of scars in patients at the clinic and how the injections had been obtained. Patients attending the clinic ...

Correction: Short-term efficacy of rofecoxib and diclofenac in acute shoulder pain: A placebo-controlled randomized trial. PLoS Clin Trials 2(5): e24.