نتایج جستجو برای: p63 protein
تعداد نتایج: 1236271 فیلتر نتایج به سال:
PURPOSE p63 is proposed to play roles in normal development and differentiation of stratified epithelia including urothelium. We recently reported that impaired p63 expression is a common feature of high-grade invasive urothelial carcinomas and associates with reduced beta-catenin. On the basis of these facts, we proposed that impaired p63 expression contributes to biological aggressiveness of ...
Development of the epidermis, the outer layer of the skin formed of keratinocytes, requires the activity of the transcription factor p63, since p63-/mice are born without epidermis and consequently die at birth. The TP63 gene contains two distinct promoters, which drive the expression of two proteins, one with an amino-terminal trans-activation domain (TAp63) and one without (Np63), although t...
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress
The p63 gene product regulates epithelial morphogenesis and female germline integrity. In this study, we show that cyclin-dependent kinase 5 and Abl enzyme substrate 1 (Cables1) interacts with the trans-activating (TA) p63alpha isoform to protect it from proteasomal degradation. Using the female germline of Cables1-null mice as an in vivo model, we demonstrate further that oocytes lacking Cable...
p63, a homologue of the tumor suppressor p53, is critical for the development and maintenance of squamous epithelia. p63 is specifically expressed in the basal layers of stratified epithelial tissues and is considered a specific marker for cells of this type. The role of p63 in tumorigenesis remains poorly defined. Numerous studies have highlighted the oncogenic potential of the predominant p63...
BACKGROUND The presence of myoepithelial cells (MECs) in fine-needle aspiration biopsies (FNAB) of the breast constitute an important criterion used to diagnose benign breast lesions. However, MECs sometimes have a distorted cytomorphology, and most of the previously evaluated myoepithelial markers do not have satisfactory sensitivity and specificity. p63, a recently characterized p53 homolog, ...
Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the DeltaNp63alpha protein. We found that MDM2 binds DeltaNp63alpha in the nucleus promoting its translocation to the cytoplasm. The MDM2 nuclear localization signal is required for DeltaNp63alpha nuclear export and subsequent degradation, whereas th...
The transcription factor p63 plays a pivotal role in keratinocyte proliferation and differentiation in the epidermis. However, how p63 regulates epidermal genes during differentiation is not yet clear. Using epigenome profiling of differentiating human primary epidermal keratinocytes, we characterized a catalog of dynamically regulated genes and p63-bound regulatory elements that are relevant f...
The role of p53 family member p63 in oncogenesis is the subject of controversy. Limited research has been done on the clinical implications of p63 expression in diffuse large B-cell lymphoma (DLBCL). In this study, we assessed p63 expression in de novo DLBCL samples (n=795) by immunohistochemistry with a pan-p63-monoclonal antibody and correlated it with other clinicopathologic factors and clin...
PURPOSE The p63 gene, located on chromosome 3q27-28, is a member of the p53 gene family. The product encoded by the p63 gene has been reported to be essential for normal development. EXPERIMENTAL DESIGN In this study, we examined the expression pattern of p63 in human normal and tumor tissues by immunohistochemistry using a monoclonal antibody (clone 4A4) that recognizes all p63 splice varian...
زمینه: سرطان غیرملانومایی پوست شامل کارسینوم سلول بازال و کارسینوم سلول سنگفرشی بوده که شایعترین بدخیمیهای انسان میباشند. هدف این مطالعه بررسی میزان بروز ژن P63 در سرطانهای معمول پوست و ضایعات غیرتومورال پوست ومقایسه این دو میباشد. مواد و روشها: در این مطالعه توصیفی- مقطعی، نمونهگیری از بلوکهای بایگانی شده سالهای 1389 و 1390 بیماران در بیمارستان شهید محمدی بندر عباس انجام شد. بدین ترتی...
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