The link between PI3K and cancer is among the strongest in the genome. PI3K sits in a critical node in cancer signaling space where it integrates growth and survival signals from RTKs and Ras to the mTOR, MAPK, FOXO1 and GSK3β signaling pathways. The Class I PI3Ks are dimeric kinases comprised of one regulatory subunit (p85 α, β, or γ) and one catalytic subunit (p110 α, β, or γ) which phosphory...