BACKGROUND The utility of intramuscular (IM) oxytocin for the prevention of postpartum hemorrhage in resource-poor settings is limited by the requirement for temperature-controlled storage and skilled staff to administer the injection. We evaluated the safety, tolerability and pharmacokinetics (PK) of a heat-stable, inhaled (IH) oxytocin formulation. METHODS This phase 1, randomized, single-c...

In addition to fight-or-flight, humans dem onstrate tending and befriending responses to stress? responses underpinned by the hormone oxytocin, by opi oids, and by dopaminergic pathways. A working model of affiliation under stress suggests that oxytocin may be a biomarker of social distress that accompanies gaps or problems with social relationships and that may provide an impetus for affiliati...

The oxytocinergic system is critically involved in the regulation of maternal behavior, which includes maternal aggression. Because aggression has been linked to anxiety, we investigated the maternal aggression and the role of brain oxytocin in lactating Wistar rats selectively bred for high anxiety-related behavior (HAB) or low anxiety-related behavior (LAB) during the 10 min maternal defense ...

Oxytocin and its receptor are synthesised in the heart and blood vessels but effects of chronic activation of this peripheral oxytocinergic system on cardiovascular function are not known. In acute studies, systemic administration of low dose oxytocin exerted a protective, preconditioning effect in experimental models of myocardial ischemia and infarction. In this study, we investigated the eff...

Oxytocin is a neuromodulator with antidepressant-like effects. In vitro, oxytocin is rapidly cleaved by insulin-regulated aminopeptidase (IRAP). Oxytocin metabolites are known to exert strong central activities that are different from the effects of the parent molecule. Our goal is to investigate in vivo whether IRAP deletion modifies the antidepressant-like effects of oxytocin. Male and female...

LIGGINS, G.C. (1962) Acute water retention associated with continuous slow infusion of oxytocin. Journal of Obstetrics and Gynaecology of the British Commonwealth, 69, 277. LIGGINs G.C. (1963) Antidiuretic effects of oxytocin, morphia and pethidine in pregnancy and labour. Australian and New Zealand Journal of Obstetrics and Gynaecology, 3, 81. LILIEN, A.A. (1968) Oxytocin induced water intoxic...

While the contractile effect of oxytocin on uterine artery has been reported, little is known about whether pregnancy affects the responsiveness of this artery to oxytocin. If it does, is it a consequence of changed endothelial function, as has been proposed for some other vasoconstrictors. Furthermore, the receptor subtypes involved in oxytocin action on uterine artery has not been yet determi...

Abstract Background: Insufficient uterine activity or hypotonic uterine contraction is a common reason and the cause of abnormal labor progress that can be corrected with oxytocin. Realizing this fact that undue prolongation of labor may contribute to prenatal morbidity has resulted in using oxytocin infusion in different kinds of ineffective uterine contractions. Materials and methods: In th...

There is growing interest in examining oxytocin and social functioning in human and non-human primates. Studies of human oxytocin biology are typically restricted to peripheral assessments because opportunities to collect cerebrospinal fluid (CSF) are rare. Several studies have examined CSF oxytocin levels in captive adult primates, but none to our knowledge have been conducted under free-rangi...