Pd(MeCN)2Cl2 enables the α-stereoselective catalytic synthesis of 2,3-unsaturated O-glycosides from O(3)-acylated glycals without the requirement for additives to preactivate either donor or nucleophile. Mechanistic studies suggest that, unlike traditional (η3-allyl)palladium-mediated processes, the reaction proceeds via an alkoxy-palladium intermediate that increases the proton acidity and oxy...

High-dose methylprednisolone pulse therapy is widely used in patients with severe COVID-19. This known to have sufficient clinical effectiveness, but the optimal administration method not known. In this study, we assessed deterioration of oxygenation after COVID-19 according disease severity (oxygen requirement) at initiation therapy. Ninety-nine who received Saitama Medical University Hospital...

BACKGROUND Bronchiolitis imposes the largest health care burden on non-elective paediatric hospital admissions worldwide, with up to 15 % of cases requiring admission to intensive care. A number of previous studies have failed to show benefit of pharmaceutical treatment in respect to length of stay, reduction in PICU admission rates or intubation frequency. The early use of non-invasive respira...

1 CYCLIC STRETCH INCREASES VEGF EXPRESSION IN PULMONARY ARTERIAL SMOOTH MUSCLE CELLS VIA TGF-β 1 AND REACTIVE OXYGEN SPECIES: A REQUIREMENT FOR NAD(P)H OXIDASE Eugenia Mata-Greenwood Albert Grobe 2,3 Sanjiv Kumar Yelina Noskina Stephen M. Black 2,3 From the Department of Pediatrics, Northwestern University, Chicago, IL, the Department of Biomedical and Pharmaceutical Sciences and the Internatio...

volume, and total lung capacity.5 Any reduction in pulmonary mechanical efficiency must be avoided in respiratory failure, and controlled use of carbimazole may permit a fall in basal metabolic oxygen requirement but with thyroid function remaining within the normal range. Carbimazole would seem suitable for a double-blind controlled trial of treatment in chronic irreversible respiratory failur...

A carbon nanotube-gold nanohybrid was used as catalyst for the reduction of molecular oxygen in acidic and alkaline media, the relevant cathode reaction in fuel cells. In alkaline medium, the nanohybrid exhibits excellent activity with a dominant 4e(-) reduction of O2 and low overpotential requirement compared to previously reported nano-gold materials. This property is linked to its capability...

The 2016 Albert Lasker Basic Medical Research Award is being awarded to Gregg Semenza, William Kaelin, and Peter Ratcliffe for discovery of the pathway by which human and animal cells sense and adapt to changes in oxygen availability-an essential requirement for survival. Bill and Peter joined Cell editor João Monteiro in an informal conversation about science, medicine, designing experiments, ...

a necessity. This is particularly true in the diabetic and the nondiabetic patient with "small vessel" or end-artery disease. Unlike occlusive disease affecting major arterial trunks, these individuals have involvement of small arteries and arterioles supplying the skin and subcutaneous tissue where development of a collateral network is at a minimum. Consequently, when injury or infection incr...