UNLABELLED Patients with COPD using long-term oxygen therapy (LTOT) over 15 h per day have improved outcomes. As inhalation of dry cold gas is detrimental to mucociliary clearance, humidified nasal high flow (NHF) oxygen may reduce frequency of exacerbations, while improving lung function and quality of life in this cohort. In this randomised crossover study, we assessed short-term physiologica...

SUMMARY Cerebral blood flow, oxygen, glucose, lactate, and pyruvate metabolism were measured in 13 subjects with completed stroke. Cerebral blood flow and oxygen consumption were reduced, glucose consumption and pyruvate production were normal, and lactate production was increased, suggesting a shift from aerobic to anaerobic cerebral glycolysis. To test this hypothesis, cerebral blood flow and...

Goddard, P., Keith, I., Marcovitch, H., Roberton, N. R. C., Rolfe, P., and Scopes, J. W. (1974). Archives of Disease in Childhood, 49, 853. Use of a continuously recording intravascular oxygen electrode in the newborn. The use of a continuously recording intravascular Po, electrode is described. The electrode, based on the Galvanic principle, is built into the tip of a French gauge (FG) 5 umbil...

The regional cerebral metabolism-to-perfusion imbalance has been studied in the three main categories of cerebrovascular disorders in a chronic phase of the disease, using the non-invasive oxygen-15 inhalation technique. In patients presenting with a history of transient ischaemic attacks, regional defects in cerebral perfusion were greater than for the corresponding oxygen uptakes. Areas of re...

PURPOSE Adherence to inhalation therapy is a critical determinant of the success of chronic obstructive pulmonary disease (COPD) management. However, in practice, nonadherence to inhalation therapy is very common in COPD patients. The effects of adherence to inhalation therapy in COPD have not been fully studied, and less is known about the relationship between medication adherence and quality ...

Many drugs may be administered either as a powder, a spray, or a nebulised aerosol. Even though the formulation is the same, the more common drugs are available in different inhaler device brands, or as a solution/suspension to aerosolise in a nebuliser system with unspecified characteristics. What formulation and type of inhalation device to choose is dependent upon factors such as type of dru...