background: the blocking of nitric oxide synthase (nos) activity may reason vasoconstriction with formation of reactive oxygen species. propolis has biological and pharmacological properties, such as antioxidant. the aim of this study was to examine the antioxidant effects of propolis which natural product on biochemical parameters in brain and lung tissues of acute nitric oxide synthase inhibi...

background: the aim of this study was to investigate the role of oxidative stress in the pathology of ovine dicrocoeliasis. methods : during dec 2013 - oct 2014, seventy-two sheep (1-3 years) with liver dicrocoeliasis along with 47 healthy sheep were selected from animals admitted for slaughtering at slaughterhouse located in neyshabour, razavi khorasan province, iran. results : in comparison t...

the aim of this study was to investigate the protective role of vitamin e against vancomycin-induced nephrotoxicity. there are some evidences that oxidative injury could be involved in its pathogenesis. vitamin e at doses of 50, 100 and 200 mg/kg were administered s.c. to rats 30 min prior to i.p. injection of 200 mg/kg vancomycin (van). drug administrations were done every 12 h for 7 days. aft...

background: it is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. the aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (htn) rats. methods: experiments were performed...

background: diabetes mellitus in some clinical cases is accompanied with hyperalgesia. in this study, we evaluated the possible beneficial effect of chronic pelargonidin (pg) treatment on hyperalgesia in streptozotocin (stz)-diabetic neuropathic rat. methods: male wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, pg-treated control, pg (single- and multiple-dose)-trea...

background: gallic acid (ga) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti‑inflammatory, anti‑cancer, and anti‑fungal properties. the aim of this study was to assess the protective effect of ga on cyclophosphamide (cpa)‑induced hepatotoxicity in male wistar rats. methods: sixty rats were grouped into six groups of 10 rats per group. group 1 recei...

cardiac disorders remain one of the most important causes of death in the world. oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. there is a large body of evidence that a...

schiff base sal-2,5-clan = 2-(2,5-dichlorobenzylideneamino)phenol used as a new precursor for preparation of poly-2-(2,5-dichlorobenzylideneamino)phenol (pdcbap). in an aqueous alkaline medium, naocl oxidant is capable of oxidative poly-condensation reaction (op). both sal-2,5-clan and pdcbap were characterized by solubility tests, ft-ir, 1h-nmr spectroscopy and tg-dta studies. ft-ir and 1h-nmr...

sperm is particularly susceptible to reactive oxygen species (ros) during critical phases of spermiogenesis. however, the level of seminal ros is restricted by seminal antioxidants which have beneficial effects on sperm parameters and developmental potentials. mitochondria and sperm plasma membrane are two major sites of ros generation in sperm cells. besides, leukocytes including polymer phonu...