The objective was to evaluate possible pharmacokinetic and pharmacodynamic interactions for repeated nightly zolpidem dosing with fluoxetine. Twenty-nine healthy female volunteers (mean age, 25. 6 years) received zolpidem (10 mg) and fluoxetine (20 mg) in the following open design: zolpidem on night 1 followed by 1 washout day, a daily morning dose of fluoxetine on days 3 through 27, and a morn...

Many kinds of computer vision problems can be formalized as statistical estimation problems with nuisance parameters. In the past, such problems have been solved without making any distinction between the nuisance parameters and structural ones. However, a theory of statistics suggests that eliminating the nuisance parameters by assuming a probability distribution on them improves estimation ac...

Journal of the Malta College of Pharmacy Practice 23 In this paper an overview will be given of how knowledge of pharmacokinetic mechanisms determines which pharmacokinetic characteristics an AED should have. Various clinical factors such as age, underlying physiological conditions and drug interactions will also affect the pharmacokinetics and efficacy of AED medication. It will be shown how b...

In this article, we consider the free boundary value problem for one-dimensional compressible bipolar Navier-Stokes-Possion (BNSP) equations with density-dependent viscosities. For general initial data with finite energy and the density connecting with vacuum continuously, we prove the global existence of the weak solution. This extends the previous results for compressible NS [27] to NSP.

EMU is a wide-field radio continuum survey planned for the new Australian Square Kilometre Array Pathfinder (ASKAP) telescope, due to be completed in 2012. The primary goal of EMU is to make a deep (∼10μJy/bm rms) radio continuum survey of the entire Southern Sky at 1.4 GHz, extending as far North as +30◦ declination, with a 10 arcsec resolution. EMU is expected to detect and catalog about 70 m...

The m-testing of model specification pioneered by Newey (1985) and Tauchen (1985) and extended by White (1987) offers a general framework that unifies many specification tests in the literature. Within the m-testing framework, we consider how to test the hypothesis that a model is correctly specified in each of many groups in the population under study, where each of the groups offers only a fe...

Multidimensional lossless networks are of special interest for use as reference structures for multidimensional wave digital filters [1]-[3]. The starting point of the presented synthesis procedure for two-dimensional representatives of the networks mentioned is a scattering matrix description of the desired multiport. This given matrix is assumed to have those properties which have turned out ...