type 2 diabetes mellitus (t2dm) is recognized as a public health problem and increasingly prevalent illness. key elements of the guideline for diabetes care are based on evidence-based medicine approach and apply for population, not individuals. however, individualized care can improve diabetes management. personalized medicine is otherwise called precision medicine tries to find better predict...

Transplantation of bone marrow cells from nonobese diabetic (NOD) mice, a model for type 1 diabetes mellitus, to C3H/HeN mice, which express I-E alpha molecules and have aspartic acid at residue 57 of the I-A beta chain, induced insulitis followed by overt diabetes in the recipient C3H/HeN mice more than 40 weeks after bone marrow transplantation. When cyclosporin A, which perturbs T-cell funct...

Recent studies have revealed that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction or dementia, especially those related to Alzheimer's disease (AD). Basic research suggests that insulin accelerates Alzheimer-related pathology through its effects on the amyloid beta (Abeta). Several pathological studies with autopsy samples have demonstrated, however, that dementia sub...

purpose: to report five cases of wolfram syndrome, an autosomal recessive neurodegenerative disease with ِdiabetes insipidus, diabetes mellitus, optic atrophy, and deafness (didmoad syndrome). patients and findings: all of the five patients had diabetes mellitus and optic atrophy. four patients had hearing loss. in spite of persistence of polyuria and polydipsia, diabetes insipidus had been prev...

Diabetes mellitus is a global epidemic affecting more than 150 million persons and it is expected that this number is likely to double by 20251. Diabetic nephropathy is the leading cause of chronic kidney disease in patients starting renal replacement therapy and is associated with increased cardiovascular mortality. Renal involvement in patients with diabetes is defined by the appearance of lo...

background: diabetes mellitus is a strong risk factor for cardiovascular disease, including acute myocardial infarction (ami). management of risk factors and the other prevention services in recent years lead to a significant decrease in ami incidence. however, to examine the success of those strategies to control diabetes, this study aimed to identify the trends in prevalence of diabetes melli...

background and objective: alleviation of serum glucose level and lipid profile in diabetic patients using herbal medications is of great importance. in the present study, the effect of oral consumption of olive leaves on serum glucose level and lipid profile was investigated. materials and methods: male wistar rats were divided into four groups including control, control under treatment, diabet...