Background and aims: Iron is stored in hepatocytes in the form of ferritin and haemosiderin. There is a marked increase in iron rich haemosiderin in iron overloaded livers, and ferric iron in amounts exceeding the ferritin and haemosiderin binding capacity may promote free radical generation, causing cellular damage. The aim of this study was to characterise hepatic haemosiderin using four anti...

This paper presents a novel methodology for approximating the queue length (the number of customers in the system) distributions of time-varying non-Markovian manyserver queues (e.g., Gt/Gt/nt queues), where the number of servers (nt) is large. Our methodology consists of two steps. The first step uses phase-type distributions to approximate the general inter-arrival and service times, thus gen...

Live virtual migration is a way for achieving system load balancing in a cloud environment by transferring an active VM from one physical host to another. This way has been developed to decrease the downtime for migrating overloaded VMs, but it still consumes timeand cost, and a huge amount of memory is involved in this migration process. To overcome these drawbacks, we propose a Load Balancing...

In this paper novel technique for CPU scheduling in real time operating systems by using genetic algorithm (GA) is proposed. Proposed adaptive algorithm is a combination of existing dynamic priority driven algorithm i.e. Earliest Deadline First (EDF) and new genetic algorithm (GA) based scheduling algorithm. First we have developed GA based scheduling algorithm and tested it during both under l...

Feld’s friendship paradox states that “your friends have more friends than you, on average.” This paradox arises because extremely popular people, despite being rare, are overrepresented when averaging over friends. Using a sample of the Twitter firehose, we confirm that the friendship paradox holds for >98% of Twitter users. Because of the directed nature of the follower graph on Twitter, we a...

Overloading and polymorphism are two important aspects in object-oriented programming languages. When an class has either of these two specialities and is depicted with a state-chart which characterizes the behaviour of the class, problems arise. Such as different transition arcs are labelled with the same name but may represent similar duties on that state-chart. General state-charts (GS) can ...

Background—Excessive myocardial fibrosis impairs cardiac function in hypertensive hearts. Roles of transforming growth factor (TGF)in myocardial remodeling and cardiac dysfunction were examined in pressure-overloaded rats. Methods and Results—Pressure overload was induced by a suprarenal aortic constriction in Wistar rats. Fibroblast activation (proliferation and phenotype transition to myofibr...

In this paper, we introduce a new, session-based workload for measuring a web server performance. We define a session as a sequence of client’s individual requests. We then measure server throughput as a number of successfully completed sessions. Using a simulation model, we show that an overloaded web server can experience a severe loss of throughput measured as a number of completed sessions ...

BACKGROUND Excessive myocardial fibrosis impairs cardiac function in hypertensive hearts. Roles of transforming growth factor (TGF)-beta in myocardial remodeling and cardiac dysfunction were examined in pressure-overloaded rats. METHODS AND RESULTS Pressure overload was induced by a suprarenal aortic constriction in Wistar rats. Fibroblast activation (proliferation and phenotype transition to...