Introduction Iron-overload cardiomyopathy is a rare condition that is associated with ventricular arrhythmias. The appropriate management of patients presenting with iron-overload cardiomyopathy and ventricular tachycardia often has to be individualized. We present a case of a young man presenting with life-threatening ventricular tachycardia as a result of iron-overload cardiomyopathy and disc...

BACKGROUND Fluid overload is known to be associated with increased mortality in patients with acute kidney injury (AKI) who are critically ill. In this study, we intended to uncover whether the adverse effect of fluid overload on survival could be applied to all of the patients with AKI who received continuous renal replacement therapy (CRRT). METHODS We analyzed 341 patients with AKI who rec...

BACKGROUND We previously reported that pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits. The threshold of pressure overload was investigated in this study. METHODS Pressure overload of the left ventricle was induced by partial snare of the ascending aorta in anesthetized, open-chest rabbits. Systolic left ventricular pressure (SLVP) was elevated 50% or 3...

BACKGROUND Plasma is commonly used for vitamin K antagonist (VKA) reversal, but observational studies suggest that it is associated with transfusion-related adverse reactions (e.g., volume overload). However, this issue has not previously been addressed in a randomized controlled trial (RCT). STUDY DESIGN AND METHODS Factors associated with volume overload were examined using data from two Ph...

RATIONALE Fluid overload is common in the critically ill and is thought to contribute to oxygenation failure and mortality. Since increasing disease severity often requires more fluid for resuscitation, it is unclear whether fluid overload is a causative factor in morbidity or is simply an indicator of disease severity. OBJECTIVE Investigate the association between fluid overload and oxygenat...

Abstract Background Iron overload, which is common in patients with haematological disorders, known to have a suppressive effect on haematogenesis. However, the mechanism for this still unclear. The antioxidant curcumin has been reported protect against iron overload-induced bone marrow damage through an as-yet-unknown mechanism. Methods We established overload cell and mouse models. Mitochondr...

Oversubscription can leverage under utilized capacity in the cloud but can lead to overload. A cloud provider must manage overload due to oversubscription for maximizing its profit while minimizing any service level agreement (SLA) violations. This paper develops an understanding of oversubscription in cloud through modeling and simulations, and explores the relationship between overload mitiga...

Schwarzer M, Schrepper A, Amorim P, Osterholt M, Doenst T. Pressure overload differentially affects respiratory capacity in interfibrillar and subsarcolemmal mitochondria. Am J Physiol Heart Circ Physiol 304: H529 –H537, 2013. First published December 15, 2012; doi:10.1152/ajpheart.00699.2012.—Years ago a debate arose as to whether two functionally different mitochondrial subpopulations, subsar...

BACKGROUND Enzymatically modified isoquercitrin (EMIQ) is produced from rutin using enzymatic hydrolysis followed by treatment with glycosyltransferase in the presence of dextrin to add glucose residues. EMIQ is absorbed in the same way as quercetin, a powerful antioxidant reported to prevent disused muscle atrophy by targeting mitochondria and to have ergogenic effects. The present study inves...