Purpose: To investigate the effect of microRNA-16 (miR-16) on glioma cell migration and invasiveness, mechanism involved.Methods: MicroRNA-16 mimic or inhibitor was transfected into human (SHG44) cells. Cell migration, invasiveness morphology were determined using scratch test, Transwell invasion assay, immunohistochemical staining, respectively. Expressions bcl-2, MMP-9 MMP-2, NF-κB1 proteins ...

Accumulation of amyloid-? (A?) is implicated in the pathogenesis and development Alzheimer's disease (AD) it a prime suspect for causing neuronal loss cognitive deficits during AD. To explore mechanisms A?-induced neurodegeneration, we used A?-treated primary cortical neuron culture as cell model AD investigated function miR-137 this process. qRT-PCR western blot were to examine levels miR-137,...

BACKGROUND To investigate the overexpression of Metastasis-associated gene 1(MTA1) protein and its relationship to the prognosis in esophageal squamous cell cancer after esophagectomy. METHODS 174 patients with middle third squamous cell carcinoma of the esophagus underwent complete resection in Provincial Hospital Affiliated to Shandong University between January 2002 and January 2005. The o...

317 Background: The effect of overexpression of epidermal growth factor receptor (EGFR) in pancreatic carcinoma is uncertain. In this study, we examine the association between EGFR overexpression (membrane and cytoplasmic) and histopathologic features and clinical outcomes in patients post resection. METHODS Seventy three patients underwent curative resection for pancreatic cancer from 4/08 t...