Bladder infections caused by uropathogenic Escherichia coli (UPEC) depends on the ability of E. coli to express type 1 pili. The adhesive component of the pilus, FimH, mediates the invasion of E. coli into the bladder epithelium, a mechanism that facilitates the survival and persistence of E. coli in the bladder. The invasion mechanism requires actin polymerization, focal adhesion kinase phosph...

PURPOSE To study the role of sensory dysfunction of bladder mucosa in bladder oversensitivity of rats with metabolic syndrome. MATERIALS AND METHODS Female Wistar rats were fed a fructose-rich diet (60%) or a normal diet for 3 months. Based on cystometry, the fructose-fed rats (FFRs) were divided into a group with normal detrusor function or detrusor overactivity (DO). Acidic adenosine tripho...

Previous reports have indicated that calcium is necessary to support active sodium transport by the toad bladder, and may be required as well in the action of vasopressin on both toad bladder and frog skin. The structure and function of the toad bladder has been studied in the absence of calcium, and a reinterpretation of the previous findings now appears possible. When calcium is withdrawn fro...

The active contour model [8,9,2] is one of the most well-known variational methods in image segmentation. In a recent paper by Bresson et al. [1], a link between the active contour model and the variational denoising model of Rudin-Osher-Fatemi (ROF) [10] was demonstrated. This relation provides a method to determine the global minimizer of the active contour model. In this paper, we propose a ...

Bladder cancer is the seventh most common cancer in the UK. It is the most frequently occurring tumour of the urinary system and accounts for around 1 in every 30 new cases of cancer each year in the UK. Bladder cancer is the 4th most common cancer in men and the 11th most common in women. The overall incidence in the UK is 11.4 per 100,000 population. Bladder cancer is the cause over more than...

Bladder cancer is the seventh most common cancer in the UK. It is the most frequently occurring tumour of the urinary system and accounts for around 1 in every 30 new cases of cancer each year in the UK. Bladder cancer is the 4th most common cancer in men and the 11th most common in women. The overall incidence in the UK is 11.4 per 100,000 population. Bladder cancer is the cause over more than...

Our understanding of the pathogenesis of bladder cancer has improved considerably over the past decade. Translating these novel pathobiological discoveries into therapies, prevention, or strategies to manage patients who are suspected to have or who have been diagnosed with bladder cancer is the ultimate goal. In particular, the chemoprevention of bladder cancer development is important, since ...

Bladder cancer is the seventh most common cancer in the UK. It is the most frequently occurring tumour of the urinary system and accounts for around 1 in every 30 new cases of cancer each year in the UK. Bladder cancer is the 4th most common cancer in men and the 11th most common in women. The overall incidence in the UK is 11.4 per 100,000 population. Bladder cancer is the cause over more than...