polycystic ovary syndrom (pcos) is characterized by infertility, oligomenorrhea, and hyperandrogenism. clomiphene citrate (cc), an antiestrogen, is first-line treatment for pcos, if cc fails to induce ovulation, laparascopic electrocautery of the ovaries is offered. in this prospective controlled study, 52 women with clomiphen-resistant pcos (group 1) and 46 women with regular menstrual cycles ...

The aim of the study was to evaluate ovarian toxicity of tyrosine kinase inhibitor (TKI) sunitinib, since only scarce data are available on gonadal function after this treatment. Six-week-old female mice received orally, once daily, vehicle or sunitinib (50 mg/kg/d) during 5 weeks. Fertility parameters were analyzed from ovulation to litter assessment. Sunitinib exposure significantly reduced (...

A complementary DNA (cDNA) copy of the aromatase P-450 has been isolated from a chicken ovary library using as probe a partial cDNA believed to encode the human placental aromatase. The predicted amino acid sequence of the chicken aromatase cDNA possesses regions of homology to that of its human counterpart, but only limited homology to other cytochrome P-450 enzymes. The introduction of the cD...

14 days p. p.) were maintained in organ culture for periods ranging from 2 to 14 days. Histological sections of these gonads were compared with controls that were fixed immediately after removal from coeval animals. It was found that germ cells in fetal ovaries progress through meiotic prophase at the same rate in culture as they do in vivo, although the number of germ cells was reduced if the ...

BACKGROUND To investigate the relationship between adiponectin, metabolic and hor- monal parameters, and insulin resistance in patients with non-treated polycystic ovary syndrome. MATERIALS AND METHODS In this cross-sectional observational study, 81 patients admitted to out-patient clinic with complaints of menstrual irregularity, hirsutism and obesity were enrolled. Serum adiponectin, bioche...

Nowadays, RAS mutational status remains a key determinant in mCRC patients’ therapeutic algorithm. Mutations involving codon 61 are rare, accounting for 1-4%, but have been recently identified with high frequency ctDNA of pts secondary resistance to anti-EGFR mAbs, prevalence 50% the Chronos trial. Despite growing clinical relevance these mutations, evidence on clinicopathological features and ...

Seyed Mohammad Ali Shariatzadeh & Zahra Alizadeh Department of Biology, Faculty of Sciences, Arak University, Arak, Iran Correspondent author: Seyed Mohammad Ali Shariatzadeh, [email protected] Abstract. Silver nanoparticles (Ag NPs) can affect female fertility because they can cause toxicity in the ovaries. The aim of this study is to see if Spirulina platensis (SP) can protect m...

This study was designed to determine the efficiency and rate of testosterone (T) retrograde transfer during the follicular and luteal phase of the estrous cycle in gilts (n=27). The efficiency and the rate of the retrograde transfer of T from the ovarian effluent into blood supplying the ovary were determined for the first time under in vivo conditions. Ovarian arterial blood concentration of T...

Primary ovarian carcinoid tumors of the ovary are rare and represent less than 0.1% of ovarian malignancy. One of its subtypes is the strumal carcinoid in which the thyroid tissue is seen in intimate association with carcinoid tumor. We here report a 47-year-old woman with strumal carcinoid of the right ovary presented with cessation of menstrual periods in the past 3 months and was referred du...

Background: Genetic polymorphism is responsible for variations and individual differences. Polymorphism is a major factor of complex diseases with unknown etiology and cancer. Inconsistency in the symptoms of polycystic ovary syndrome (monthly disorder, hirsutism, obesity, diabetes, infertility) is one of the major pathological complications of this syndrome. The present study was conducted to ...