OBJECTIVE: The aim of this study is to evaluate the outcomes gonadotropin-releasing hormone agonist treatment for ovarian cysts, which are developed during tamoxifen use due breast cancer. STUDY DESIGN: This was a retrospective cohort including patients who were under stage I-III cancer and administered leuprolide acetate cysts with low malignancy risk between 2012-2020. RESULTS: Leuprolide tot...

NF-κB signaling promotes cancer progression in a large number of malignancies. Metadherin, a coactivator of the NF-κB transcription complex, was recently identified to regulate different signaling pathways that are closely related to cancer. We assessed the immunohistochemical expression of p50, p65, and metadherin in 30 ovarian carcinomas, 15 borderline ovarian tumours, and 31 benign ovarian c...

INTRODUCTION Ovarian cancer is one of the leading health problems, as it is the underlying cause of disease and deaths of a large number of women around the world. Postmenopausal female population, in whom ovarian carcinoma is most often diagnosed in advanced stages of the disease, is primarily affected. MATERIAL AND METHODS We used data from Hospital Registry for Malignant Neoplasms at Oncol...

Various trials of ovarian cancer screening programs have been reported worldwide. In 2011, one of the most famous papers indicated that annual screening using CA125/transvaginal sonography (TVS) did not reduce ovarian cancer mortality in the United States of America (USA). To investigate the validity of ovarian cancer screening, we verified the analyses of previous reports. At first, we obtaine...

background: ovarian cancer comprises a heterogeneous group of neoplasms. the prognosis cannot be predicted by histopathologic examination alone. the aim of this study is to evaluate p53, pten, and β-catenin expressions in primary ovarian carcinomas in an attempt to find a possible relationship with morphologic parameters and clinical findings. methods: the study included 100 epithelial ovarian ...

Background & Objective: Epithelial ovarian cancer (EOC) is the most prevalent type of cancer. Previous studies have elucidated different pathways for progress this malignancy. The mutation in B-Raf proto-oncogene, serine/threonine kinase (BRAF) gene, a member MAPK/ERK signaling pathway, plays role EOC. current study aimed to determine frequency BRAF V600E serous and mucinous tumors, including b...

Hydroxamate-based histone deacetylase inhibitors (Hb-HDACIs), such as vorinostat, belinostat and panobinostat, have been previously shown to have a wide range of activity in hematologic malignancies such as cutaneous T-cell lymphoma and multiple myeloma. Recent data show that they synergize with a variety of cytotoxic and molecular targeted agents in many different solid tumors, including breas...