We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14α-demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholesterol. LKO mice developed hepatomegaly with oval cell proliferation, fibrosis and inflammation, bu...

Six-, 12and 20-week-old rats were fed N-nitrosomorpholine (NNM) at low concentrations (6 mg/kg/day) or high concentrations (20 mg/kg/day) for 6 or 12 weeks. Irrespective of the age of the rats, both NNM schedules resulted in development of hepatomas and during the early stages of hepatoma induction, liver histotoxic patterns depended only on the dose of carcinogen employed. Necrosis of hepatocy...

It is also important to determine if the malleus is mobile by massaging the tympanic membrane under a Siebel otoscope and microscope. If the malleus is mobile, a normal stapedectomy can be performed, consisting of an incus to oval window prosthesis. This operation has a high rate of success (95%). If the malleus is fixed, however, it is necessary to create a malleus to oval window prosthesis. B...

The purpose of this study is both theoretically and experimentally to clarify the dynamic stress of a discharge reed valve with oval shape, and to get fundamental knowledge for the design of this type valve and its related parts. The strain measurements were performed on the strain gauge bonded on the surface of the oval shaped reed valve. The stress and deformation of the valve were also calcu...

OBJECTIVES To comparatively evaluate the preparation of oval root canals with a rotary or an oscillating system. STUDY DESIGN The middle and coronal parts of 55 extracted permanent teeth with oval canals were prepared using FlexMaster (FM) rotary NiTi instruments and EndoEze AET (EE) stainless steel oscillating instruments. Pre- and postoperative images of cross-sections were superimposed to ...

The hepatic stem cells reside periportally forming the canals of Hering in normal liver. They can be identified by their unique immunophenotype in rat. The oval cells, the progenies of stem cells invade deep the liver parenchyma after activation and differentiate into focally arranged small-and eventually trabecularly ordered regular hepatocytes. We have observed that upon the completion of int...

We present the first large-scale comparison of the spatial distribution of field-aligned currents as measured by the Active Magnetosphere and Planetary Electrodynamics Response Experiment, with the location and brightness of the average auroral oval, determined from the Imager for Magnetopause-to-Aurora Global Exploration far ultraviolet instrument. These distributions are compared under the sa...

Let F be a flock of the quadratic cone Q: X 2=X1X3 , in PG(3, q), q even, and let 6t : X0 =xt X1 + t X2 +zt X3 , t # Fq , be the q planes defining the flock F. A flock is equivalent to a herd of ovals in PG(2, q), q even, and to a flock generalized quadrangle of order (q, q). We show that if the herd contains a monomial oval, this oval is the Segre oval. This implies a result on the existence o...

The 6-min walk test (6MWT) is a common component of fitness assessments of older adults; however, differing course configurations might affect 6MWT performance. It is unclear how comparable 2 different configurations are. To determine the comparability of 2 courses, 35 adults >65 years of age completed two 6MWT, once walking around a 20- by 5-yd outdoor rectangle and once on an indoor oval trac...

The expression of cellular myc (c-myc) was studied during early and late stages of chemical hepatocarcinogenesis in the rat using Northern blot analysis and in situ hybridization. Hepatocarcinogenesis was induced according to the resistant hepatocyte model of Solt and Farber. An uninitiated version of this model was also used to examine the expression of c-myc during proliferation and different...