نتایج جستجو برای: outer hair cells

تعداد نتایج: 1459809  

Journal: :Hearing research 1988
L D Fechter J S Young L Carlisle

Previous studies have determined that severe systemic hypoxia disrupts cochlear function acutely, but have suggested that augmentation of cochlear perfusion may successfully protect cochlear function under all but the most profound hypoxic treatments. In the current study we report on the chronic effects of simultaneous exposures to noise and carbon monoxide on pure tone thresholds and hair cel...

Journal: :Neuroreport 2006
Shinya Ugawa Akira Inagaki Hisao Yamamura Takashi Ueda Yusuke Ishida Kenji Kajita Hideo Shimizu Shoichi Shimada

We investigated whether amiloride-blockable proton-gated cation channels ASIC1a (acid-sensing ion channel-1a) and ASIC1b are expressed in the stereocilia of mouse cochlear hair cells. In-situ hybridization studies showed that ASIC1b transcripts, but not ASIC1a transcripts, were expressed in the inner and outer hair cells. Fluorescent immunohistochemical and immunogold electron microscopic analy...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Waheeda A Hossain Srdjan D Antic Yang Yang Matthew N Rasband D Kent Morest

The origin of the action potential in the cochlea has been a long-standing puzzle. Because voltage-dependent Na+ (Nav) channels are essential for action potential generation, we investigated the detailed distribution of Nav1.6 and Nav1.2 in the cochlear ganglion, cochlear nerve, and organ of Corti, including the type I and type II ganglion cells. In most type I ganglion cells, Nav1.6 was presen...

Journal: :The Journal of clinical investigation 2001
K Yano L F Brown M Detmar

The murine hair follicle undergoes pronounced cyclic expansion and regression, leading to rapidly changing demands for its vascular support. Our study aimed to quantify the cyclic changes of perifollicular vascularization and to characterize the biological role of VEGF for hair growth, angiogenesis, and follicle cycling. We found a significant increase in perifollicular vascularization during t...

Journal: :Developmental dynamics : an official publication of the American Association of Anatomists 2010
Chan Ho Hwang Dayong Guo Marie A Harris Omar Howard Yuji Mishina Lin Gan Stephen E Harris Doris K Wu

The mammalian organ of Corti of the inner ear is a highly sophisticated sensory end organ responsible for detecting sound. Noggin is a secreted glycoprotein, which antagonizes bone morphogenetic proteins 2 and 4 (Bmp2 and Bmp4). The lack of this antagonist causes increased rows of inner and outer hair cells in the organ of Corti. In mice, Bmp2 is expressed transiently in nascent cochlear hair c...

Journal: :Current Biology 2008
Joseph Santos-Sacchi

Mammalian hearing is boosted by mechanically active auditory receptor cells, the outer hair cells which amplify the actions of incoming sounds. Recent evidence indicates that the molecular motor that drives this amplification, prestin, may do more than boogie.

2002
Gary Zajic Jochen Schacht

Shape changes can be induced in isolated outer hair cells by various stimuli and quantified from digitized video-images. While overall changes in length between base and apex are easily measured, changes in defined segments of the cell require fixed landmarks on the cell body. The problem of locating such landmarks makes it difficult to assess if a change in length is uniform or largely confine...

Journal: :Journal of the American Academy of Audiology 2003
Margarett S Parker Nkeiruka N Onyenekwu Richard P Bobbin

Cochleae of guinea pigs were evaluated for the presence of the metabotropic receptor, P2Y4. Evidence is presented that P2Y4 protein is expressed in the guinea pig cochleae using Western blot analysis. A single protein band of 35 kDa was detected with P2Y4 receptor-specific antibody. The cellular distribution of P2Y4 purinoceptor protein was determined by immunohistochemistry of the whole organ ...

Journal: :Mechanisms of Development 1998
B. C. Powell E. A. Passmore A. Nesci S. M. Dunn

The Notch signalling pathway is an important mediator of cell fate selection whose involvement in epidermal appendage formation is now becoming recognised. Hair follicle development and hair formation involve the co-ordinated differentiation of several different cell types in which Notch appears to have a role. We report intricate expression patterns for the Notch-1 receptor and three ligands, ...

Journal: :Nihon Jibiinkoka Gakkai kaiho 1978
T Aoki

By the use of frozen resin cracking method , scanning electron microscopy (SEM) makes it possible to investigate the deeper and finer structures of the inner ear. Another merit of this method is to obtain any sections of the organs without any significant artifactual damages to the tissues. The inner ears of the guinea pig were fixed and stained with osmic acid. After the cracking procedure fro...

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