Multiple mammalian lineages independently evolved a definitive mammalian middle ear (DMME) through breakdown of Meckel's cartilage (MC). However, the cellular and molecular drivers of this evolutionary transition remain unknown for most mammal groups. Here, we identify such drivers in the living marsupial opossum Monodelphis domestica, whose MC transformation during development anatomically mir...

Techniques and biomaterials for reconstructive middle ear surgery are continuously and steadily developing. At the same time, clinical post-surgery results are evaluated to determine success or failure of the therapy. Routine quality assessment and assurance is of growing importance in the medical field, and therefore also in middle ear surgery. The exact definition and acquisition of outcome p...

UNLABELLED Facial paralysis can result from a variety of etiologies; the most common is the idiopathic type. Evaluation and treatment are particularly complex. The treatment of acute facial paralysis may require facial nerve decompression surgery. Any structure near the path of the facial nerve is at risk during transmastoid decompression surgery. AIM This is a retrospective study, carried ou...

BACKGROUND Recently, a model of the ossicular chain for finite element analysis has been developed. However, the natural vibration characteristics of human ossicles have never been studied. Herein, we investigated the dynamic characteristics of the coupling of in-vivo ossicles using finite element analysis. METHODS The geometry of the ossicular chain was obtained by high-resolution computed t...

Abstract. Khatulistiani TS, Dewi AS, Yasman. 2022. Detailed description of scanning electromagnetic microscope (SEM) the Holothuria scabra’s ossicles (Holothuroidea: Echinodermata) collected from Pesawaran waters, Lampung, Indonesia. Biodiversitas 23: 3697-3704. Ossicles are microscopic calcified endoskeleton that unique across sea cucumber species. Furthermore, their integrity is maintained af...

The middle ear ossicles are important due to transmission of sound to the inner ear leading to sound understanding. The aim of present study was to determine the anatomical and morphometrical aspects of middle ear ossicles in Makouei sheep fetuses. For this experimental study, eight sheep fetuses at the age of 2 to 3 months were provided from public slaughterhouse; their middle ear ossicles wer...

On account of the complex structure of the middle ear and that it is more difficult to carry out experiments to test the nature of the mechanical components, the relevant data is hard to obtain, which has become an obstacle restricting analysis of the middle ear mechanic. Based on spatial structure and mechanical properties of ossicular chain, the paper has established functional relationship b...

Ossicular repositioning and ossicular prostheses are said to offer an oppotunity to preserve the air space of the middle ear and improve the transmission of sound to the stape footplate. Depending upon the pathological circumstances, any convenient remaining portion of the auditory ossicles may be used to reconstruct a functioning ossicular chain. But the problem of reconstruction is not simple...

OBJECTIVE: This study aims to analyze factors influencing the recurrence of acquired pediatric cholesteatoma that has impact on operative plan decision. PATIENTS AND METHODS: Retrospective review of 62 children (68 ears) with acquired middle ear cholesteatoma who underwent surgery from 1995 to 2006. Age distribution at initial operation ranged from 3 to 16 years with mean age of 11.2 years. Sur...

The use of genetically modified mice can accelerate progress in auditory research. However, the fundamental profile of mouse hearing has not been thoroughly documented. In the current study, we explored mouse middle ear transmission by measuring sound-evoked vibrations at several key points along the ossicular chain using a laser-Doppler vibrometer. Observations were made through an opening in ...