Object-substitution masking (OSM) is thought to reflect a failure of object individuation. That is, a briefly presented target surrounded by four dots is perceptually fused with the four-dot mask when the mask is visible after the target has disappeared, thereby obscuring the visibility of the target. If OSM depends on the inability to temporally segregate objects, then increasing the temporal ...

Environmental stress during early development can impact adult phenotypes via programmed changes in gene expression. C. elegans larvae respond to environmental stress by entering the stress-resistant dauer diapause pathway and resume development once conditions improve (postdauers). Here we show that the osm-9 TRPV channel gene is a target of developmental programming and is down-regulated spec...

The paper presents results from a validation process of OpenStreetMap (OSM) rapid mapping activities using crowdsourcing technology in the aftermath of the Gorkha earthquake 2015 in Nepal. We present a framework and tool to iteratively validate and update OSM objects. Two main objectives are addressed: first, analyzing the accuracy of the volunteered geographic information (VGI) generated by th...

Over the last couple of years Volunteered Geographic Information (VGI) and particularly OpenStreetMap (OSM) have emerged as an important additional source of information in disaster management. The so-called OSM Crisis Maps are primarily developed by OSM contributors who work remotely. While local OSM contributors know their area of interest and rely upon local knowledge, often the sole basis f...

With the advent of location-aware smartphones, the desire for pedestrian-based navigation services has increased. Unlike car-based services where instructions generally are comprised of distance and road names, pedestrian instructions should instead focus on the delivery of landmarks to aid in navigation. OpenStreetMap (OSM) contains a vast amount of geospatial information that can be tapped in...

Tolvaptan (TLV), a vasopressin type 2 receptor antagonist, has been demonstrated to be effective in patients with decompensated heart failure (HF) refractory to incremental doses of diuretics, but the responsiveness has not always been predictable. We have recently proposed that urine osmolality (U-OSM) is a valuable parameter for the prediction of responses to TLV, because U-OSM reflects the a...

OBJECTIVE Macrophages produce the cytokine oncostatin M (OSM), which beside other functions is also involved in inflammation. The complement component C5a mobilizes and activates these cells at inflammatory sites. We examined the effect of C5a on OSM production in human monocytes and in human monocyte-derived macrophages. METHODS AND RESULTS For macrophage transformation peripheral blood mono...

OBJECTIVES Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integrity. This study assesses the effects of a RetA + OSM combination on cartilage catabolism. METHODS Animal and human cartilage samples were used to assess the ability of RetA + OSM to promote the release of collagen and proteoglycan fragments, which wa...

The OpenStreetMap (OSM) project, a well-known source of freely available worldwide geodata collected by volunteers, has experienced a consistent increase in popularity in recent years. One of the main caveats that is closely related to this popularity increase is different types of vandalism that occur in the projects database. Since the applicability and reliability of crowd-sourced geodata, a...

Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor beta subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus. In the present study, we investigated the development of OSMR-positive neurons of DRGs in OSM-deficient mice. In ...