The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol (LA) or cycloartenol (CA). This is catalyzed by an oxidosqualene cyclase (OSC). LA and CA are subsequently converted into various sterols by a series of enzyme reactions. The specificity of the OSC therefore determines the final composition of the end sterols of an organism. Despite...

A new application of emphatic orthogonal signal correction (EOSC) for baseline correction of near infrared spectra from reflectance measurements of tissue sections is introduced. EOSC was evaluated and compared with principal component orthogonal signal correction (PC-OSC) by using support vector machine (SVM) classifiers. In addition, some exemplary synthetic data sets were created to characte...

Among all of the slope stability methods, use of stone columns and geosynthetic elements can be a good way for stabilizing. One of the efficient ways in order to reinforce earth slopes is Geogrid Encased Stone Column (GESC). This technique can dramatically increase bearing capacity and decrease settlement rate. The aim of this paper is experimentally to investigate a comparison between the beha...

The capacity for myocardial perfusion depends on the structure of the coronary microvascular bed. Coronary microvessels may adapt their structure to various stimuli. We tested whether the local pressure profile affects tone and remodeling of porcine coronary microvessels. Subendocardial vessels (approximately 160 microm, n=53) were cannulated and kept in organoid culture for 3 days under differ...

Yes-associated protein 1 (YAP1) is a key transcriptional regulator in the Hippo signaling pathway that plays a critical role in the development and progression of several types of malignancies, including ovarian cancer. Herein, we investigated the expression of YAP1 and its clinical significance in a large population of patients with ovarian serous cystadenocarcinoma (OSC), which is the most co...

Ten years ago, Bhattacherjee proposed the information system continuance model, which received considerable attention in the literature. This study proposes an extended information system continuance model by incorporating system quality to the original model in the context of educators’ utilization of e-learning technology for conducting courses. Our proposed model is tested using a sample of ...

Although interorganizational information system can facilitate supply chain integration and supply chain agility, unintended outcomes may occur if partners possess distinct knowledge about the use of IOS. Based on Foucault’s theory of power/knowledge, institutional theory and resource dependence theory, we analyze how various power relations work together to facilitate the institutionalization ...

A malicious cloud user may exploit outsourced data involved in online communication, co-residency, and hypervisor vulnerabilities to breach hamper sensitive information, inject traffic based congestion, rendering services other benign users. To address this critical challenging problem, letter proposes an Online Secure Communication Model for Cloud (OSC-MC) by identifying terminating VMs inter-...

Linear discriminant analysis (LDA) is a classical statistical approach for dimensionality reduction and classification. In many cases, the projection direction of the classical and extended LDA methods is not considered optimal for special applications. Herein we combine the Partial Least Squares (PLS) method with LDA algorithm, and then propose two improved methods, named LDA-PLS and ex-LDA-PL...

PLS univariate regression is a model linking a dependent variable y to a set X= {x1; : : : ; xp} of (numerical or categorical) explanatory variables. It can be obtained as a series of simple and multiple regressions. By taking advantage from the statistical tests associated with linear regression, it is feasible to select the signi6cant explanatory variables to include in PLS regression and to ...