let g_1 and g_2 be simple connected graphs with disjoint vertex sets v(g_1) and v(g_2), respectively. for given vertices a_1in v(g_1) and a_2in v(g_2), a splice of g_1 and g_2 by vertices a_1 and a_2 is defined by identifying the vertices a_1 and a_2 in the :union: of g_1 and g_2. in this paper, we present exact formulas for computing some vertex-degree-based graph invariants of splice of graphs.