OBJECTIVE To investigate whether first trimester exposure to lamotrigine (LTG) monotherapy is specifically associated with an increased risk of orofacial clefts (OCs) relative to other malformations, in response to a signal regarding increased OC risk. METHODS Population-based case-control study with malformed controls based on EUROCAT congenital anomaly registers. The study population covere...

Introduction: orofacial clefts are common congenital malformations with an important social, psychological, and economic impact. The treatment of this condition may include different surgical procedures that previously require adequate oral condition. Case report: we report a case dental before palatoplasty in male patient 17 years-old bilateral cleft lip palate lesion the jugal mucosa. Final c...

Objectives: To identify the various otological challenges associated with non-syndromic orofacial clefts, how these problems affect quality of life patients clefts and find out perspectives current trends in management problems. Design: We conducted systematic searches for retrospective studies, cross-sectional case-control cohorts’ longitudinal studies prospective controlled trials Medline Goo...

STATEMENT OF THE PROBLEM Individuals with oral clefts exhibit considerably more dental anomalies than individuals without clefts. These problems could initially be among the symptoms of their disease and/or they may be the side effect of their treatments. Pushback palatoplasty could cause some interference during the development of teeth and result in tooth defects. PURPOSE The study was perf...

background: we studied the role of maternal folic acid supplementation in modifying the effects of  methylenetetrahydrofolate reductase (mthfr c677t and a1298c) gene polymorphisms in iranian children with oral clefts. materials and methods: forty?seven newborn infants with orofacial cleft and their mothers were selected randomly. mothers were matched regarding dietary folate intake.the genotypi...

OBJECTIVES To evaluate the sensitivity and specificity of ultrasound for detecting prenatal facial clefts in low-risk and high-risk populations. METHODS This study prospectively followed up a non-selected population, namely all pregnant women who underwent routine second-trimester prenatal ultrasound screening in the Utrecht region during the 2-year period from January 2007 to December 2008. ...

Microstomia may result from surgical treatment of orofacial neoplasms, cleft lips, maxillofacial trauma, burns, radiotherapy, or scleroderma. A maximal oral opening that is smaller than the size of a complete denture can make prosthetic treatment challenging. This clinical paper presents the prosthodontic management of a total edentulous patient with microstomia. Sectional mandibular and maxill...

It is also important to point out that these discrepancies are usually caused by the maxilla growth inhibition, due to the detrimental effects of the primary reconstructive plastic surgeries (cheiloplasty and palatoplasty). Therefore, the presence of orofacial characteristics such as hypoplastic maxilla, concaved mid-face and deformed dental arch can be mainly observed after plastic surgeries i...

Cleft palate is a common congenital disorder that affects up to 1 in 2,500 live human births and results in considerable morbidity to affected individuals and their families. The etiology of cleft palate is complex, with both genetic and environmental factors implicated. Mutations in the transcription factor-encoding genes p63 and interferon regulatory factor 6 (IRF6) have individually been ide...

INTRODUCTION From an epidemiological point of view, non-syndromic orofacial clefts are the most common oral congenital deformities worldwide. OBJECTIVE Family histories were traced and socioeconomic risk factors were identified for non-syndromic cleft lip with or without cleft palate. MATERIAL AND METHODS A case-control study was carried out with 208 cases of non-syndromic cleft lip with or...