Pesticides have the potential to leave harmful effects on humans, animals, other living organisms, and the environment. Several human metabolic proteins inhibited after exposure to organophosphorus pesticides absorbed through the skin, inhalation, eyes and oral mucosa, are most important targets for this interaction study. The crystal structure of five different proteins, PDBIDs: 3LII, 3NXU, 4G...

A novel capacitive field-effect sensor for the direct determination of organophosphorus pesticides by the enzyme organophosphorus hydrolase (OPH) is presented. The enzyme OPH hydrolyses organophosphorus compounds catalytically, thus releasing Hþ ions. By means of a silicon-based field-effect sensor, which consists of a layer sequence of Al/p-Si/SiO2 with alternative pH-sensitive materials (Ta2O...

Certain organophosphorus esters such as diisopropylfluorophosphate (DFP) cause delayed neuropathy by inhibition of neuropathy target esterase (NTE) keeping neuron in normal function. In this study, effects of neurobion alone and in combination with dexamethasone on DFP–induced delayed neuropathy were evaluated. Thirty-five mice were divided to five groups that each group consists 7 mice. Except...

Chlorpyrifos is an organophosphate insecticide, used to control foliage and soil-borne insect pests on a variety of food and feed crops. In the natural environment, Chlorpyrifos can be degraded  through  several  possible  processes,  including  photodegradation, biodegradation,  and hydrolysis.  In  the  present  work  the  photodegradation  and  environmental  fate  of  Chlorpyrifos  in aqueo...

The use of organophosphorus pesticides results in toxicity risk to non-target organisms. Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition. Consequently, acetylcholine accumulates in the synaptic clefts of muscles and nerves, leading to overstimulation of cholinergic receptors. Acute cholinergic crisis imm...

Objective: The goal of the study is to determine pattern dangerous material presence in field, as well how severely it affects kidney function and can result death. Methods: An observational patients hospitalized poison ward tertiary care hospitals Gwalior was planned. For data collection a structured questionnaire used, which includes questions on demographic information, details poisoned inta...

We used a novel study design to measure dietary organophosphorus pesticide exposure in a group of 23 elementary school-age children through urinary biomonitoring. We substituted most of children's conventional diets with organic food items for 5 consecutive days and collected two spot daily urine samples, first-morning and before-bedtime voids, throughout the 15-day study period. We found that ...