BACKGROUND Organophosphates are broad class of chemicals widely used as pesticides throughout the world. We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru. METHODS Thirty-one men exposed to organophosphate (OP) pesticides and 31 non-exposed were recruited (age, 2...

INTRODUCTION Investigators have hypothesized that consuming pesticide-contaminated well water plays a role in Parkinson's disease (PD), and several previous epidemiologic studies support this hypothesis. OBJECTIVES We investigated whether consuming water from private wells located in areas with documented historical pesticide use was associated with an increased risk of PD. METHODS We emplo...

Although the use of pesticides has doubled every ten years since 1945, pest damage to crops is more prevalent now than it was then. Many pests are now pesticide resistant due to the ubiquitous presence of pesticides in our environment. Chlorinated pesticide residues are present in the air, soil, and water, with a concomitant presence in humans. Organophosphate and carbamate pesticides - the com...

BACKGROUND Pesticides are an agricultural chemical suspected to be a significant contributor to a global diabetes pandemic. The purpose of this study was to confirm previous findings of the link between diabetes and some agricultural pesticides and to identify the particular pesticides that are most likely to pose a risk of diabetes in the community. METHODS A population-based case-controlled...

BACKGROUND In this investigation we documented the pesticide urinary metabolite levels of farmworker children in North Carolina, determined the number of different metabolites detected for each child, and delineated risk factors associated with the number of metabolites. METHODS Urine samples were collected from 60 Latino farmworker children 1-6 years of age (34 female, 26 male). Interviews w...

BACKGROUND Nitric oxide synthase (NOS) genes are candidates for Parkinson's disease (PD) because NOS enzymes produce nitric oxide (NO), a pro-oxidant that can damage neurons. Widely used organophosphate (OP) pesticides can induce oxidative stress and are reported to increase PD risk. Additionally, two single nucleotide polymorphisms (SNPs) from the PON1 (paraoxonase 1) gene influence the abilit...

PURPOSE To analyze the findings for Evoked Otoacoustic Emissions (EOEA) and suppression effect in workers with normal hearing exposed to pesticides and noise . METHODS The sample consisted of 55 participants with normal hearing, with ages ranging from 18 to 35 years, divided into two groups: one group exposed to noise and pesticides (GRA) and a control group (CG). The GRA was composed of 25 p...