Linkers that enable the site-selective synthesis of chemically modified proteins are great interest to field chemical biology. Homogenous bioconjugates often show advantageous pharmacokinetic profiles and consequently increased efficacy in vivo. Cysteine residues have been exploited as a route site-selectively modify proteins, many successfully approved therapeutics make use cysteine directed c...

A series of pyrroles functionalized in the 3-position with p-dimethoxybenzene via various linkers (CH2, CH2CH2, CH=CH, C≡C) has been synthesized. Their electronic properties have been deduced from (1)H NMR, (13)C NMR, and UV-vis spectra to detect possible interactions between the two aromatic subunits. The extent of conjugation between the subunits is largely controlled by the nature of the lin...

N-Heteroarene substitution into biphenyl-based linkers enhances the uptake of electron-rich organosulfur molecules in a series of isostructural microporous coordination polymers.

In the present study, a set of hydrogels were synthesized using N-isopropylacrylamide with various cross linkers at dosages via free radical polymerization. Thermal and structural properties characterized thermogravimetric analyzer (TGA) Fourier Transformation Infrared Radiation (FTIR) spectroscopy. The effect crosslinkers such as N,N´-Methylenebisacrylamide, ethylene glycol dimethacrylate (EGD...

A new route for the preparation of magneto-responsive polymeric gels involving iron nanoparticles as nano cross-linkers has been described.