Acute kidney injury (AKI) is the second prevalent organ damage among COVID-19 infected individuals, which mainly affects those with critical diseases or underlying disorders. Emerging data have suggested that AKI associated adverse outcomes, severe disease, and high mortality. However, true nature pathophysiology of COVID-19-associated injury, its effect on patients transplant recipients, still...

Severe malaria is characterised by cerebral oedema, acute lung injury (ALI) and multiple organ dysfunctions, however, the mechanisms of lung and distal organ damage need to be better clarified. Ninety-six C57BL/6 mice were injected intraperitoneally with 5×10(6)Plasmodium berghei ANKA-infected erythrocytes or saline. At day 1, Plasmodium berghei infected mice presented greater number of areas w...

With over 110,000 patients waiting for organ transplantation, the current crisis in organ transplantation is based on a lack of donors after brain-death (DBD). A very large alternative pool of donor organs that remain untapped are the donors after cardiac death (DCD), recovered after cardiac activity has ceased and therefore sustained some ischemic injury. Machine perfusion has been proposed as...

Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's endogenous protective capabilities against the injury incurred by ischaemia and reperfusion. It describes the intriguing phenomenon in which transient non-lethal ischaemia and reperfusion of one organ or tissue confers resistance to a subsequent episode of lethal ischaemia reperfusion injury in a remote orga...

Background: The term caustic generally refers to alkaline and the term corrosive generally refers to acidic agents' injury however, in medical literature caustic is frequently a term applied to both substances. Ingested alkali typically damage the esophagus more than stomach or duodenum, whereas acids usually cause more severe gastric injury. Since esophagus has a slightly alkaline pH, its epit...

Kidney machine perfusion kidney transplantation, machine perfusion, organ preservation, hypothermic/normothermic perfusion, ischemia/ reperfusion injury

STUDY OBJECTIVES Cardiac surgery with cardiopulmonary bypass (CPB) is associated with major inflammatory triggers that cause marked activation of the microcirculation. This inflammatory response is associated with significant organ dysfunction. How this response causes organ dysfunction is not well understood; consequently, few interventions exist to prevent or treat it. In other acute inflamma...

Purpose: Renal injury occurs in up to 5% of trauma cases and the kidney is third most wounded abdominal organ. The study objective was analyze clinical characteristics patients with blunt renal review treatment high-grade injuries.Methods: medical charts who visited Haeundae Paik Hospital between March 2010 February 2020 were retrospectively analyzed. Data on demographics, patterns, presentatio...

Herein we describe a pathogenic role for the Pseudomonas aeruginosa type three secretion system (T3SS) needle tip complex protein, PcrV, in causing lung endothelial injury. We first established a model in which P. aeruginosa wild type strain PA103 caused pneumonia-induced sepsis and distal organ dysfunction. Interestingly, a PA103 derivative strain lacking its two known secreted effectors, ExoU...