Fast-disintegrating tablet (FDT) technology is one of the recent innovative technologies in pharmaceutical formulations, and the FDT formulation has become a fast-growing segment in oral drug delivery systems. FDTs can be administered easily without water, although taking water makes oral administration even easier. They are suitable for children, the elderly and anyone who has a difficulty in ...

The present study was aimed towards the formulation and in vitro evaluation of rapidly disintegrating tablets by direct compression technology using Captopril as a model drug. Rapidly disintegrating tablet of Captopril was formulated using three Superdisintegrants in different concentrations i.e. 4%w/w, 8%w/w and 12%w/w and one disintegrants having concentration i.e. 2% w/w/, 4% w/w and 6% w/w ...

Fast-disintegrating tablets of furosemide (FS) were prepared by the novel direct compression method. FS, microcrystalline cellulose (MC), croscarmellose sodium (CC), xylitol (XL) and sucrose stearic acid esters (SSEs) with an hydrophilic-lipophilic balance (HLB) of 16, 15 and 11, named S1670, S1570 and S1170, were used. An FS/SSE/MC mixed powder was obtained by solvent evaporation of a suspensi...

OBJECTIVE To investigate the disintegration profile, acceptability, and tolerability of orally disintegrating risperidone tablets in patients with schizophrenia or schizoaffective disorder. METHOD Ten patients stable for at least 10 days on monotherapy with oral risperidone 2 mg to 4 mg taken once daily were switched for 7 days to an equivalent dosage of orally disintegrating risperidone. Vis...

Risperidone is a white to slightly beige powder. It is practically insoluble in water, freely soluble in methylene chloride, and soluble in methanol and 0.1 N HCl. RISPERDAL® tablets are available in 0.25 mg (dark yellow), 0.5 mg (red-brown), 1 mg (white), 2 mg (orange), 3 mg (yellow), and 4 mg (green) strengths. Inactive ingredients are colloidal silicon dioxide, hypromellose, lactose, magnesi...

10.2217/14750708.5.2.203 © 2 Parkinson’s disease is a neurodegenerative disorder manifested by a combination of motor and non-motor symptoms. Levodopa, a dopamine precursor, is the most efficacious drug available to control the symptoms of Parkinson’s disease. Almost all other medications with symptomatic benefit for Parkinson’s disease show their effect by facilitating the dopaminergic system,...

Cardiovascular disease (CVD) is the leading cause of death among men and women worldwide. In CVD, hypertension and dyslipidemia commonly coexist and are managed through coadministration of amlodipine and atorvastatin, respectively. The case for fixed-dose combination (FDC) oral dosage forms and orally disintegrating tablet (ODT) technology to enhance outcomes and compliance is strong. This work...

An efficient disintegrant is capable of breaking up a tablet in the smallest possible particles in the shortest time. Until now, comparative data on the efficacy of different disintegrants is based on dissolution studies or the disintegration time. Extending these approaches, this study introduces a method, which defines the evolution of fractal dimensions of tablets as surrogate parameter for ...

In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner's ratio, Carr's index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by A...