Cancer-associated fibroblasts are amongst the key tumor microenvironment components that determine invasion, progression, and resistance to cancer therapeutics. Histologically normal mucosa adjacent oral squamous cell carcinoma has been shown harbor cancer-associated which aid in loco-regional recurrence of lesion. Read more at JCTRes.com

Apigenin, a flavonoid commonly present in the daily diet, is known for its potential anti-tumor properties. However, the effect of apigenin via oral administration on tumor growth and metastasis remains unknown. In this study we developed an orthotopic ovarian tumor model in nude mice to test the effect of apigenin oral administration, and showed that apigenin inhibited the micrometastasis of c...

Background and Aim: Oral mucosal lesions have various prevalence rates among different populations. Few studies have evaluated the frequency of oral mucosal lesions in Iranian population. This study aimed to determine the frequency of oral mucosal lesions and the related factors.                   &nb...

Mounting effective anti-tumor immune responses against tumors by both the innate and adaptive immune effectors is important for the clearance of tumors. However, accumulated evidence indicates that immune responses that should otherwise suppress or eliminate transformed cells are themselves suppressed by the function of tumor cells in a variety of cancer patients, including those with oral canc...

Oral cancer is a common neoplasm worldwide. Its incidence and mortality have also increased over the past decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. Metastasis of oral cancer is a complex process involving detachment of cells from tumor tissue, regulation of cell motility and invasion, proliferation and ...

Acanthosis nigricans (AN) is a rare condition which may affect oral cavity. There are two forms of AN: benign and malignant. Benign AN may be hereditary, or may be related to systemic diseases or drugs. Malignant AN is most often associated with gastric adenocarcinoma but cancers of other sites and types may also occur. This case report is based on a case of a 78-year-old woman suffering from i...

Oral cancer is one of the most disfiguring types of cancer, since the surgical removal of the tumor may result in facial distortion. Oral cancer is also known to exhibit "field cancerization", resulting in the development of a second primary tumor. Furthermore, the five-year survival rate of this disease has remained approximately 50% during the past 30 years. Prevention and early detection/tre...

Oral Malignant Melanoma (OMM) are the most frequent neoplasmsin dogs older than 10 years, and represent up to 7% of all malignant tumors in dog. Small breeds, with especially heavily pigmented oral mucosa greater risk get disease. The outcome OMM is related clinical stage at presentation e.g. tumor size, presence local or distant spread metastases, absence ulceration anatomic site. treatment co...

Background The oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial lining of the oral cavity, accounting for about 95% of malignant lesions in this region. In Brazil, the oral cavity is the fifth location of the highest incidence of cancer in men and the seventh in women. In 2012, Brazil was estimated at 9,990 new cases of oral cancer in men and 4,180 in ...

BACKGROUND Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses. MATERIAL AND M...