Peutz Jegher’s syndrome is a mucocutaneous autosomal dominant condition associated with extensive melanin pigmentation and intestinal hamartomatous polyp formation. It is characterised by round, oval patches of blackish brown pigmentation, irregularly distributed over the oral mucosa, lips, tongue and the hard palate. This condition is associated with an increased risk towards carcinoma and sev...

OBJECTIVES Oral tongue cancer may have a distinct epidemiological profile from other mucosal neoplasms of the oral cavity. We sought to further define the demographic characteristics associated with oral tongue cancer to determine if unique characteristics exist compared with other oral cavity cancers. STUDY DESIGN Cross-sectional analysis using cross-tabulations and multivariate regression m...

Carcinomas are the major serious health issue in today’s healthcare system. while its prognosis is difficult at earlier stages. OSSC oral squamous cell carcinomas reported more than 3 lakhs new cases world-wide and it sixth most common cancer world-wide. Squamous carcinoma defined as of soft, flat, thin cells mainly affect soft regions like tongue diagnosed by various investigational imaging bi...

OBJECTIVE To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge. DESIGN Retrospective matched-pair cohort study. SETTING Memorial Sloan-Kettering Cancer Center, New York, New York. ...

In an era where mutational profiles inform treatment options, it is critical to know the extent to which tumor biopsies represent the molecular profile of the primary and metastatic tumor. Head and neck squamous cell carcinoma (HNSCC) arise primarily in the mucosal lining of oral cavity and oropharynx. Despite aggressive therapy the 5-year survival rate is at 50%. The primary objective of this ...

INTRODUCTION Several molecular markers have been studied for their usefulness as prognostic markers in oral squamous cell carcinoma (OSCC). One such molecular marker is cyclin D1 which is a proto-oncogene located on 11q13 in humans. OBJECTIVE To explore the feasibility of using cyclin D1 as a prognostic marker in tongue and cheek SCC by the fluorescent-in-situ hybridization (FISH) method. M...

Spindle cell carcinoma (SpCC), a rare, aggressive variant of squamous cell carcinoma (SCC), is characterised by proliferation of epithelial and mesenchymal components. It is important to diagnose this variant of SCC, because of its tendency to recur and early metastasis. It accounts for 1% of all tumours in the oral cavity. In this paper, we have reported a case of SpCC of the tongue in a 65-ye...

AIM The purpose of this article is to report a rare case of primary tuberculosis of the tongue. BACKGROUND Tuberculosis is an infectious, chronic granulomatous disease that can involve almost any organ in the body, but primary lesions are usually confined to the lungs. Oral lesions are an infrequent occurrence in tuberculosis, and tuberculosis of the oral cavity is often a consequence of acti...

We were the first to demonstrate that direct application of the environmental pollutant and tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) into the oral cavity of mice induced squamous cell carcinoma (SCC) in oral tissues but not in the tongue; however, the mechanisms that can account for the varied carcinogenicity remain to be determined. Furthermore, we also showed that not only dA a...

Cancer of the oral cavity, also known as “oral cavity cancer” or more simply “oral cancer”, affects the tongue, gingiva, floor of mouth, palate, tonsils and oropharynx.1, 2 However, the most common form of oral cancer, oral squamous cell carcinoma (OSCC), can affect any tissue lined with oral mucosal epithelium.2, 3 Oral cancer is one of the most common malignancies in the world, ranking eighth...