Many e-commerce websites struggle to turn visitors into real buyers. Understanding online users’ realtime intent and dynamic shopping cart choices may have important implications in this realm. This study presents an individual-level, dynamic model with concurrent optimal page adaptation that learns users’ real-time, unobserved intent from their online cart choices, then immediately performs op...

As an important tumor suppressor protein, reactivate mutated p53 was found in many kinds of human cancers and that restoring active p53 would lead to tumor regression. In this work, we developed a new computational method to predict the transcriptional activity for one-, two-, three- and four-site p53 mutants, respectively. With the approach from the general form of pseudo amino acid compositio...

Species differ enormously in their territorial systems. Some species defend only small areas surrounded by undefended space, while others defend large contiguous territories. Using an optimization approach, we show that this variation can be explained from the density of two types of resources: divisible and nondivisible. We assume that benefits of territories are monotonously related to the de...

BACKGROUND Provision of optimal postoperative analgesia should facilitate postoperative ambulation and rehabilitation. An optimal multimodal analgesia technique would include the use of nonopioid analgesics, including local/regional analgesic techniques such as surgical site local anesthetic infiltration. This article presents a novel approach to surgical site infiltration techniques for abdomi...

The on-site generation of electricity can offer building owners and occupiers financial benefits as well as social benefits such as reduced grid congestion, improved energy efficiency, and reduced greenhouse gas emissions. Combined heat and power (CHP), or cogeneration, systems make use of the waste heat from the generator for site heating needs. Real-time optimal dispatch of CHP systems is dif...

This study proposes an optimization model for optimal treatment of bacterial infections. Using an influence diagram as the knowledge and decision model, we can conduct two kinds of reasoning simultaneously: diagnostic reasoning and treatment planning. The input information of the reasoning system are conditional probability distributions of the network model, the costs of the candidate antibiot...

Background Rural health houses constitute a major provider of some primary health services in the villages of Iran. Given the challenges of providing health services in rural areas, health houses should be established based on the criteria of health network systems (HNSs). The value of these criteria and their precedence over others have not yet been thoroughly investigated. The present study w...

When setting up patients via image-guided positioning for external-beam radiotherapy, one can often determine the rotational corrections needed for optimal alignment, but once measured, they are not always applied. However, in rigid-body setup calculations the optimal translational component of the setup correction will be different depending on whether rotations are included or excluded from t...

the anterior cruciate ligament (acl) is composed of two bundles, which work together to provide both antero-posterior and rotatory stability of the knee. understanding the anatomy and function of the acl plays a key role in management of patients with acl injury. anatomic acl reconstruction aims to restore the function of the native acl. femoral and tibial tunnels should be placed in their anat...

We introduce the frugal foraging model in which a forager performs a discrete-time random walk on a lattice in which each site initially contains S food units. The forager metabolizes one unit of food at each step and starves to death when it last ate S steps in the past. Whenever the forager eats, it consumes all food at its current site and this site remains empty forever (no food replenishme...