Breast cancer is one of the most common cancers among the population of the Western world. Diagnostic methods include mammography, ultrasound, and magnetic resonance; meanwhile, nuclear medicine techniques have a secondary role, being useful in regional assessment and therapy followup. Optical imaging is a very promising imaging technique that uses near-infrared light to assess optical properti...

Holography has paved the way for phase imaging in a variety of wide-field techniques, including electron, X-ray and optical microscopy. In scanning optical microscopy, however, the serial fashion of image acquisition seems to challenge a direct implementation of traditional holography. Here we introduce synthetic optical holography (SOH) for quantitative phase-resolved imaging in scanning optic...

We report the optical imaging of a single atom with nanometer resolution using an adaptive optical alignment technique that is applicable to general optical microscopy. By decomposing the image of a single laser-cooled atom, we identify and correct optical aberrations in the system and realize an atomic position sensitivity of ≈ 0.5 nm/ √ Hz with a minimum uncertainty of 1.7 nm, allowing the di...

Cardiovascular disease typically is associated with dysfunction of the coronary vasculature and microvasculature. The study of cardiovascular disease typically involves imaging of the large coronary vessels and quantification of cardiac blood perfusion. These methods, however, are not well suited for imaging of the cardiac microvasculature. We used the optical histology method, which combines c...

An optical imaging technique called ultrasound-modulated optical computed tomography is demonstrated for tomographic imaging of biological tissues. Ultrasound-modulated optical signals are extracted from scattered light to provide projection data for the image reconstruction. A filtered back-projection algorithm is implemented to reconstruct an image reflecting optical tissue properties from an...

Functional optical coherence tomography (fOCT) is used to record optical changes that correspond to spontaneous and stimulated electrical activity in neural tissue. FOCT provides a high-resolution, real-time, non-invasive method for investigating neurophysiology. 2003 Optical Society of America OCIS codes: (170.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170...

This article reviews two types of ultrasound-mediated biophotonic imaging-acousto-optical tomography (AOT, also called ultrasound-modulated optical tomography) and photo-acoustic tomography (PAT, also called opto-acoustic or thermo-acoustic tomography)-both of which are based on non-ionizing optical and ultrasonic waves. The goal of these technologies is to combine the contrast advantage of the...

Introduction : Multi-modality imaging is becoming a trend in developing new generation in vivo imaging techniques for diagnosis [1]. MRI is a high resolution imaging modality, while optical imaging provides essential functional information such as oxygen saturation in the diseased tissue. In addition, when the contrast agent is administrated, the sensitivity and specificity for each imaging com...

PILOT (the Pathfinder for an International Large Optical Telescope) is a proposed Australian/European optical/infrared telescope for Dome C on the Antarctic Plateau, with target first light in 2012. The proposed telescope is 2.4m diameter, with overall focal ratio f/10, and a 1 degree field-of-view. In median seeing conditions, it delivers 0.3" FWHM widefield image quality, from 0.7-2.5 microns...