Enabled by the ultrahigh-speed all-optical wavelength-swept mechanism and broadband optical amplification, amplified optical time-stretch optical coherence tomography (AOT-OCT) has recently been demonstrated as a practical alternative to achieve ultrafast A-scan rate of multi-MHz in OCT. With the aim of identifying the optimal scenarios for MHz operation in AOT-OCT, we here present a theoretica...

PURPOSE To report the foveal structural findings of hypotony maculopathy imaged with optical coherence tomography. METHODS Case report of a 39-year-old white woman with a 20 year history of uveitis, who underwent pars plana vitrectomy and pars plana Baerveldt implant for intractable glaucoma. Four months postoperatively, decreased vision and hypotony maculopathy ensued. Optical coherence tomo...

We describe fiber-based quadrature low-coherence interferometers that exploit the inherent phase shifts of 3 x 3 and higher-order fiber-optic couplers. We present a framework based on conservation of energy to account for the interferometric shifts in 3 x 3 interferometers, and we demonstrate that the resulting interferometers provide the entire complex interferometric signal instantaneously in...

Broadband light generation from a single-mode optical fiber was developed for high-resolution optical coherence tomography (OCT). No noise amplification was observed for light broadened by self-phase modulation. The investigation showed that the intensity noise of light broadened by self-phase modulation in a single-mode optical fiber was much lower than that of continuum light from a microstru...

Purpose To report the anatomic and functional recovery of the ellipsoid zone in a case of acute idiopathic blind spot enlargement (AIBSE), which was documented by serial high-resolution optical coherence tomography imaging. Observations The patient's clinical presentation and follow up visits were documented via Humphrey's Visual Fields, fundus autofluorescence, and high resolution spectral d...

PURPOSE To utilize optical coherence tomography (OCT) and OCT angiography (OCTA) to describe alterations in the retinal and choriocapillaris vasculature following remote laser photocoagulation. Lesions are classified on the basis of choriocapillaris alteration as evaluated on en face OCTA. METHODS This was a retrospective, cross-sectional study analyzing 28 laser photocoagulation scars from 8...

AIM To compare the difference of retinal macular thickness and macular volume using optical coherence tomography (OCT) in primary open angle glaucoma (POAG) patients with the normal subjects. MATERIALS AND METHODS This observational case control study included primary open angle glaucoma (POAG) patients (n = 124 eyes) and healthy subjects in the control group (n = 124 eyes). All subjects unde...

Title of Document: AUTOMATED QUANTIFICATION AND CLASSIFICATION OF HUMAN KIDNEY MICROSTRUCTURES OBTAINED BY OPTICAL COHERENCE TOMOGRAPHY Qian Li, Master of Science, 2009 Directed By: Assistant Professor, Yu Chen, Department of Bioengineering Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, high-resolution images of tissue ...

OBJECTIVE To investigate the ability of optical coherence tomography (OCT) to assess changes in retinal nerve fiber layer (RNFL) thickness in optic disc edema. METHODS Prospective observational case series in a private eye clinic (Centro Salus). Twelve consecutive eyes (9 patients) with optic disc edema were analyzed, including 6 patients with anterior ischemic optic neuropathy, 1 patient wit...

OBJECTIVES To determine the feasibility of long-range optical coherence tomography (LR-OCT) as a tool to intraoperatively image and measure the subglottis and trachea during suspension microlaryngoscopy before and after endoscopic treatment of subglottic stenosis (SGS). METHODS Long-range optical coherence tomography of the adult subglottis and trachea was performed during suspension microlar...