OBJECTIVE This study is to investigate the in vivo apoptotic processes in glioma tissues following cryoablation and the effects of glioma tissue extracts on GL261 glioma cells in vitro. METHODS TUNEL and flow cytometry analysis were performed to detect the apoptotic processes in the glioma tissues following cryoablation and in the GL261 cells treated with cryoablated tumor extracts. The scrat...

BACKGROUND Previous studies support a role for mitogen-activated protein kinase pathway signaling, and more recently Akt/mammalian target of rapamycin (mTOR), in pediatric low-grade glioma (PLGG), including pilocytic astrocytoma (PA). Here we further evaluate the role of the mTORC1/mTORC2 pathway in order to better direct pharmacologic blockade in these common childhood tumors. METHODS We stu...

Case 1 Patient A. O., an 8-year-old school pupil presented to the Eye Clinic of the University College Hospital, Ibadan with a 3 year history of gradual painless protrusion of the left eye. She lost vision in the eye 4 months before presentation. The general examination was normal. No features of neurofi bromatosis were found. The visual acuity were 6/5 and NLP in the right and left eyes respec...

Both Notch signaling and Akt-mTOR signaling pathway are involved in glioma cell proliferation and survival. Previous studies have shown that Notch-1 is overexpressed in many glioma cell lines and primary human gliomas. Blocking of Notch signaling pathway can induces glioma cell apoptosis and growth suppression. However, the underlying molecular mechanism is not clear. We report that activation ...

Case presentation: IL, 5 years old, female, weighing 28,5kg, previously healthy. Sought medical attention due to intense and progressive headache for a year, worsening in the previous 90 days, followed by vomiting. Cranial magnetic resonance showed an intraparenchymal lesion optic chiasm suggestive of inflammatory injury infection or cancer, raising hypothesis tuberculosis pathway glioma. Cereb...

Glioma is the most common type of brain tumor and according to the 2016 WHO classification, based on invasion level, it is divided into four categories. The most severe and invasive type is grade IV glioma or glioblastoma (GBM), which has a very poor prognosis and a survival rate of only 15 months. However, the molecular pathway of invasion in malignant glioma tumors has not yet been clearly el...