PURPOSE To evaluate the effect of disease severity and optic disc size on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular parameters with RTVue (Optovue, Fremont, CA) spectral domain optical coherence tomography (SDOCT) in glaucoma. METHODS 110 eyes of 62 normal subjects and 193 eyes of 136 glaucoma patients from the Diagnostic Innovations in...

In this paper, we purpose a diagnostic procedure to identify the optic nerve disease from visual evoked potential (VEP) signals using an Artificial Neural Network (ANN). Multilayer feed forward ANN trained with a Levenberg Marquart backpropagation algorithm was implemented. The correct classification rate was 96.87% for subjects having optic nerve disease and 96.66% for healthy subjects. The en...

Glaucoma which is a leading cause of blindness in the world is not a single disease but a group of disorders with diverse clinical manifestations. If not controlled at an early stage, it causes irreversible damage to vision. Proper medication slows down or even halts its growth. Identifying glaucoma at a very early stage is vital and at the same time difficult. Careful evaluation of Optic nerve...

The regenerative failure of mammalian optic axons is partly mediated by Socs3-dependent inhibition of Jak/Stat signaling (Smith et al., 2009, 2011). Whether Jak/Stat signaling is part of the normal regenerative response observed in animals that exhibit an intrinsic capacity for optic nerve regeneration, such as zebrafish, remains unknown. Nor is it known whether the repression of regenerative i...

Introduction: Optic neuropathies are a broad group of diseases in which the dominant disturbance is damage to optic nerve, often irreversible. Underlying causes neuropathy both genetic and environmental. Despite limited treatment options, much research currently being done on substances that could improve nerve function alleviate clinical consequences damage.
 Purpose: This article describ...

Background The majority of the patients affected by a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre EPF or pemphigus Abreu-Manu), have experienced vision problems; we have previously reported several ocular abnormalities. Methods Here, we aimed to investigate reactivity to optic nerves in these patients. We utilized bovine, rat and mouse optic nerves, and performe...

Sarcoidosis of the optic nerve is reported in 1 %-5% of sarcoid patients [1]. Even though it is the second most frequently affected cranial nerve in this disease [1, 2], its involvement has not been demonstrated previously by computed tomography (CT) [3-12]. In addition, despite pathologic descriptions of granulomatous infiltration of the falx [13, 14], transfalcine spread of sarcoidosis has no...

An autoradiographic method (14C-iodoantipyrine autoradiography) was used to measure regional optic nerve blood flow (ONBF) under basal conditions in 11 adult female cats. Flow was measured in six regions of the optic nerve: (1) prelaminar, (2) laminar, (3) 1 mm post-laminar, (4) 4 mm post-laminar, (5) 6 mm post-laminar, and (6) intracranial optic nerve and chiasm. A gradient of flow rates was f...