BACKGROUND AND PURPOSE Evaluating chronic sequelae of optic neuritis, such as optic neuropathy with or without optic nerve atrophy, can be challenging on whole brain MRI. This study evaluated the utility of dedicated coronal contrast-enhanced fat-suppressed FLAIR (CE-FS-FLAIR) MR imaging to detect optic neuropathy and optic nerve atrophy. MATERIALS AND METHODS Over 4.5 years, a 3 mm coronal C...

BACKGROUND AND PURPOSE Increases in apparent diffusion coefficient (ADC) from diffusion-weighted (DW) imaging are thought to be due to axonal disruption, and changes have been well documented in multiple sclerosis lesions. DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisecti...

A 52-year-old man presented with an anterior communicating artery aneurysm associated with splitting, penetration, and visual symptoms of the optic nerve and manifesting as sudden onset of severe headache. Angiography disclosed a 10-mm anterior communicating artery aneurysm projecting supero-posteriorly, and operative findings revealed unexpected splitting of the optic nerve. Moreover, the opti...

Optic neuritis is a common presentation of demyelinating disorders such as multiple sclerosis. It typically presents with acute painful monocular vision loss, whereas chronic optic neuropathy can be caused by compressive lesions along the anterior visual pathway, genetic, toxic, or nutritional causes. We report an unusual presentation mimicking optic neuritis, which was subsequently diagnosed a...

To investigate the role of tenascin-R in nervous system development, we studied axon pathfinding in the developing optic system of zebrafish. Zebrafish tenascin-R has the same domain structure as tenascin-R in amniotes. Amino acid sequence identity with human tenascin-R is 60%. In 3-d-old larvae, tenascin-R mRNA is expressed in scattered cells throughout the periventricular cell layer of the di...

BACKGROUND AND PURPOSE There is a well-known relationship between MS and damage to the optic nerve, but advanced, quantitative MR imaging methods have not been applied to large cohorts. Our objective was to determine whether a short imaging protocol (< 10 minutes), implemented with standard hardware, could detect abnormal water diffusion in the optic nerves of patients with MS. MATERIALS AND ...

PURPOSE To evaluate the signal characteristics of the optic papilla (optic nerve head) on routine cranial MR images in patients with clinical evidence of optic papilla elevation caused by high intracranial pressure, and to compare these findings with findings in healthy adult volunteers. METHODS We reviewed retropectively the MR imaging examinations of 15 patients who were referred with objec...

purpose: to report a case of anterior ischemic optic neuropathy (aion) after ingestion of tadalafil (a drug for management of erectile dysfunction). patient and findings: a healthy 26-year-old male was referred due to loss of vision and visual field defect in his left eye a few days after using tadalafil. visual loss was progressive during the following days. examination revealed disc swelling ...