The dynamics and parameterization of mixing in temporally evolving turbulent open-channel flow is investigated through direct numerical simulations as the transitions from an initially neutral state to stable stratification. We observe three distinctly different regimes separated by transitional values Froude number $Fr$ : a weakly stratified regime for $Fr >1$ ; intermediate $0.3< Fr<...

A series of compounds related to ameltolide were studied for anticonvulsant potential in the subcutaneous pentylenetetrazol (sc Ptz) test in mice. These compounds were synthesized and characterized by TLC followed by IR and H1NMR. In vivo screening data acquired indicate that most of analogs have the ability to protect against PTZ-induced seizure. Phenytoin (PHT) was employed as the reference p...

Present study examines turbulent structures of a rough bed open-channel flow in the context of deterministic approach. Instantaneous velocity field is measured in different hydraulic conditions using two dimensional Particle Image Velocimetry (PIV) in vertical plane and Stereoscopic PIV in horizontal plane. Different techniques and quantities such as swirl strength, two-point and cross-correlat...

In a previous study we identified an extensive gating network within the inwardly rectifying Kir1.1 (ROMK) channel by combining systematic scanning mutagenesis and functional analysis with structural models of the channel in the closed, pre-open and open states. This extensive network appeared to stabilize the open and pre-open states, but the network fragmented upon channel closure. In this st...

Wireless communication is a channel driven transmission in open environment. This channel model driven knowledge driven communication with environment propagation can increase the channel error, noise and disruption. In this paper, a study to this channel modeling and different disruption types are defined. The AWGN based channel modeling is defined in open environment. Later on the paper has d...

The present study explored whether the intercalated cell Cl(-)/HCO3(-) exchanger pendrin modulates epithelial Na(+) channel (ENaC) function by changing channel open probability and/or channel density. To do so, we measured ENaC subunit subcellular distribution by immunohistochemistry, single channel recordings in split open cortical collecting ducts (CCDs), as well as transepithelial voltage an...

1. Single-channel kinetics of steroid enhancement of single gamma-aminobutyric acidA (GABA) receptor currents obtained from somata of mouse spinal cord neurones in culture were investigated using the excised outside-out patch-clamp recording technique. GABA (2 microM) and GABA (2 microM) plus androsterone (5 alpha-androstan-3 alpha-ol-17-one, AND, 10 nM-10 microM) or pregnanolone (5 beta-pregna...