OBJECTIVE Monogenic diabetes, a young-onset form of diabetes, is often misdiagnosed as type 1 diabetes, resulting in unnecessary treatment with insulin. A screening approach for monogenic diabetes is needed to accurately select suitable patients for expensive diagnostic genetic testing. We used C-peptide and islet autoantibodies, highly sensitive and specific biomarkers for discriminating type ...

Mutation in HNF1B, the hepatocyte nuclear factor-1β (HNF-1β) gene, results in maturity-onset diabetes of the young (MODY) 5, which is characterized by gradual impairment of insulin secretion. However, the functional role of HNF-1β in insulin secretion and glucose metabolism is not fully understood. We identified a family with early-onset diabetes that fulfilled the criteria of MODY. Sanger sequ...

BACKGROUND AND AIMS Following recent reports of increased numbers of adolescents being diagnosed with the adult or type 2 form of diabetes we aimed to describe the prevalence of both type 2 and other forms of diabetes in an urban population of children and young people in northern England. METHODS A hospital based cross sectional study was performed in patients aged < or =30 years attending d...

Background & Aims: Limited joint mobility (LJM) is a complication of diabetes mellitus, which usually begins from the small joints of hands and is associated with long-term complications of diabetes, such as retinopathy and nephropathy. The aim of this study was to find the prevalence of Limited Joint Mobility in patients with type 1 diabetes mellitus in Kerman in 2003. Methods: Sixty-six patie...

OBJECTIVE Optimal prevention of young-onset type 2 diabetes requires identification of the early-life modifiable risk factors. We aimed to do this using longitudinal data in 1,604 5- to 19-year-old initially nondiabetic American Indians. RESEARCH DESIGN AND METHODS For type 2 diabetes prediction, we derived an optimally weighted, continuously distributed, standardized multivariate score (zMS)...

OBJECTIVE We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes. RESEARCH DESIGN AND METHODS Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years. RESULTS Among the 1,850 diabetic participants, 102 had IDE. ESRD developed i...

OBJECTIVE To investigate the frequencies of the major maturity-onset diabetes of the young (MODY) subtypes in a panel of Spanish families and to assess phenotypic differences in patients with the different subtypes of MODY. METHODS Forty-eight subjects from twenty families with clinical diagnosis of MODY were studied. They underwent a standardised clinical examination and a 75-g oral glucose ...