ONO-1301 has been developed as a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. In the present study, we investigated the cerebroprotective effect of ONO-1301 on post-ischemic injury induced by cerebral ischemia in rats. ONO-1301 (1 and 10 mg/kg) was administrated orally at reperfusion and then twice a day for 42 days. The cell damage induced by cerebral i...

Ru(ONO)2 and Os(ONO)2 distort from octahedral towards trigonal prismatic geometry in order to relieve π antibonding due to donation from the second-highest ligand orbital to the metal. Increasing oxidation of the ONO ligand suppresses distortion by increasing σ* interactions in the trigonal prism.

To evaluate the role of leukotriene B4 (LTB4) in glomerulonephritis, this study was conducted to examine whether ONO-4057, an LTB4 receptor antagonist, moderated nephritis caused by the injection of nephrotoxic serum (NTS) into Wistar-Kyoto rats. Rats were given intraperitoneal injections of ONO-4057 or phosphate-buffered saline 24 h before the injection of NTS. These rats subsequently received...

In this paper we prove that the Benjamin–Ono equation admits an analytic Birkhoff normal form in open neighborhood of zero H0s(T,R) for any s>−1/2 where denotes subspace Sobolev space Hs(T,R) elements with mean 0. As application show −1/2<s<0, flow map S0t:H0s(T,R)→H0s(T,R) is nowhere locally uniformly continuous a H0s(T,R).

The balance between prostacyclin and thromboxane A2 (TXA2) plays an important role in pulmonary homeostasis. However, little information is available regarding the therapeutic potency of these prostanoids for pulmonary fibrosis. We have recently developed ONO-1301, a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. Thus we investigated whether repeated admin...

A new bimetallic platform comprising a six-coordinate Fe(ONO)2 unit bound to an (ONO)M (M = Fe, Zn) has been discovered ((ONOcat)H3 = bis(3,5-di-tert-butyl-2-phenol)amine). Reaction of Fe(ONO)2 with either (ONOcat)Fe(py)3 or with (ONOq)FeCl2 under reducing conditions led to the formation of the bimetallic complex Fe2(ONO)3, which includes unique five- and six-coordinate iron centers. Similarly,...

and Applied Analysis 3 The following type of Strichartz estimate was used in [19, 20] for the study of the Benjamin-Ono equation. We refer to [12] for the counterpart to the Schrödinger equation. Lemma 5. Let T ≤ 1 and V be a solution to the equation i∂ t V + ΔV = F 1 + F 2 , (t, x) ∈ (0, T) ×R 2 . (15) Then, for δ ∈ R and ε > 0, one has 󵄩󵄩󵄩󵄩 J δ V 󵄩󵄩󵄩󵄩L p T L q ≲ ‖V‖ L ∞ T H δ+1/2+ε + 󵄩󵄩󵄩󵄩F1 󵄩...