Diphenylphosphinic acid was used as an efficient and simple catalyst for the synthesis of α-aminophosphonates by multicomponent Kabachnik-Fields reaction in one pot aromatic aldehyde, aniline diethylphosphite. Three physicochemical factors including amount, time medium temperature were optimized using a full factorial experiment design (FFD). Additionally, quadratic polynomial regression model ...

A number of nucleobase-based barbiturates have been synthesized by combination of nucleic acid bases and heterocyclic amines and barbituric acid derivatives through green and efficient multicomponent route and one pot reaction. This approach was accomplished efficiently using aqueous medium to give the corresponding products in high yield. The newly synthesized compounds were characterized by s...

The microwave assisted and solvent free synthesis of title compounds is described in this protocol. Ten new aryl imidazoles, which are incorporated with the chemotherapeutic pharmacophores, have been synthesized by adopting one pot multicomponent reaction. First, primary aromatic or heteryl amine has been condensed with aryl or heteryl aldehydes to afford corresponding Schiff base. The Schiff b...

Conjugated polymers have emerged over the past several decades as key components for a range of applications, including semiconductors, molecular wires, sensors, light switchable transistors and OLEDs. Nevertheless, the construction of many such polymers, especially highly substituted variants, typically involves a multistep synthesis. This can limit the ability to both access and tune polymer ...

in the current study, a magnetic inorganic–organic nanohybrid material (hpa/tpi-fe3o4) was produced and used as an efficient, highly recyclable and eco-friendly catalyst for the one-pot and multicomponent synthesis of 3,4-dihydroquinoxalin-2-amine, diazepine-tetrazole and benzodiazepine-2-carboxamide derivatives with high yields and in a short range of time (20–35 min). the nanohybrid catalyst ...

The one-pot synthesis of a target molecule in the same reaction vessel is widely considered to be an efficient approach in synthetic organic chemistry. In this review, the characteristics and limitations of various one-pot syntheses of biologically active molecules are explained, primarily involving organocatalytic methods as key tactics. Besides catalysis, the pot-economy concepts presented he...

ABSTRACT. One-pot, mild and efficient synthesis of various spiro-nitrogen heterocycle compounds, based on the reaction ninhydrin 1,2-diamino-benzene, (indenoquinoxalin), with N-heterocycle compounds dialkylacetylenedicarboxylates is described. Using this approach, at a temperature 50-60 °C in acetonitrile solvent, can be obtained very high yields.
 
 KEY WORDS: Ninhydrin, 1,2-Diaminob...

Abstract Supramolecular assemblies from synthetic polymers have been widely used in materials science and biological applications. Developing convenient efficient methods to tune polymer structures architectures is important for achieving desired self‐assembly behaviors. Among various strategies, multicomponent reactions drawn significant interest due the high reaction efficiency, chemical sele...