Objective: To assist the interpretation of genomic data for common epilepsies, we asked whether variants implicated in mild epilepsies in autosomal dominant families are present in the general population. Methods: We studied 12 genes for the milder epilepsies and identified published variants with strong segregation support (de novo germline mutation or $4 affected family members). These varian...

It has long been known that past-time operators add no expressive power to linear temporal logics. In this paper, we consider the extension of branching temporal logics with past-time operators. Two possible views regarding the nature of past in a branching-time model induce two different such extensions. In the first view, past is branching and each moment in time may have several possible fut...

A: It came about I was teaching my first year out of college in Portland, Oregon in 1952 in a school that I hated. The district was lower middle class, going downhill fast. There were thirty five kids in the classroom and I decided by mid-year that if I finished the year in one piece, I was not going to go back there. I could not transfer to another school in the system. The main office told me...

Education and learning have witnessed some important changes in the past few years. The appearance and success of the information society may well be one of the main factors for such change. Indeed. children are increasingly more and more at ease with the use of computers and technology. So, eapitalising on this advantage, our research aims at exploring and enriching current and new classroom a...

A three-tier application is organized as three layers. Front end clients (e.g., browsers) with which human user interact; middle-tier servers (e.g., web servers) that contain the core business logic of the application; and back-end database servers against which application servers perform transactions. Although three-tier applications are nowadays mainstream, they usually fail to provide su ci...

Individuals and nonprofit institutions may reproduce and distribute copies of this Article in any format, at or below cost, for educational purposes, so long as each copy identifies the author, provides a citation to the Notre Dame Law Review, and includes this provision and copyright notice.for their willingness to trade their valuable insights for food; to Claudia Brand for translation help; ...

Once-daily aminoglycoside dosing is effective in treating gram-negative infections, including those associated with bones and joints.