Senna villosa (Miller) is a plant that grows in México. In traditional Mexican medicine, it is used topically to treat skin infections, pustules and eruptions and to heal wounds by scar formation. However, studies of its potential anti-inflammatory effects have not been performed. The aim of the present study was to determine the anti-inflammatory effect of extracts from the leaves of Senna vil...

In this study, the synthesis of new coumarins with aliphatic chains is discussed. The incorporation 6-tert-octyl and 6,8-ditert-butyl into a coumarin structure from alkylphenols, allows obtaining hydrophobic good yields. These can be potential modulators TRPV1 receptors. Synthesis spectroscopic data these are analyzed.

The tumor promoters, 12-O-tetradecanoylphorbol-13-acetate (TPA), phorbol-12,13-didecanoate, teleocidin, and dihydroteleocidin, at nM levels, but not the non-tumor-promoting 4 alpha-phorbol-12,13-didecanoate even at microM concentrations, stimulated arachidonic acid metabolism in cultured rat liver cells. These liver cells synthesize primarily prostaglandin I2 [measured as its nonenzymatic hydro...

We have investigated the miscibility in the mixed monolayers of cholesterol (Ch)-octyl cyano biphenyl (8CB) and cholesteryl acetate (ChA)-8CB using surface manometry and epifluorescence microscopic techniques. The main skeleton is the same both in Ch and ChA, whereas the polar head group is alcohol in Ch and ester in ChA. The 8CB molecule has a polar cyano as a terminal group and we probe its i...

The relationship between calcium ions and the differentiation of human promyelocytic leukemia HL-60 cells was investigated. Proliferation of HL-60 cells incubated in calcium-free medium was inhibited without cell differentiation. On the other hand, incubation with 100 microM verapamil markedly inhibited cell proliferation and caused slight cell differentiation into monocytes. Both calcium-free ...

The complete molecule of the title compound, C 26 H 34 O 6 , is generated by a crystallographic centre symmetry and central octyl chain adopts an extended conformation. In structure, weak C—H...π interactions link molecules.

The liquid structure of aqueous solutions of five different imidazolium based gemini dicationic ionic liquids 1,n-bis(3-methylimidazolium-1-yl) alkane bromide (n being the length of the spacer alkyl chain), with propyl, pentyl, octyl, decyl and hexadecyl spacer chains has been studied using atomistic molecular dynamics simulations. While solutions with propyl and pentyl spacers are homogeneous,...

Systematically modified octyl galactosides and octyl N-acetyllactosamines were assessed as inhibitors of, and substrates for, T. cruzi trans-sialidase (TcTS) in the context of exploring its acceptor substrate binding site. These studies show that TcTS, which catalyses the α-(2→3)-sialylation of non-reducing terminal β-galactose residues, is largely intolerant of substitution of the galactose 2 ...