AIM To assess the prognostic relevance of 64-slice computed tomography coronary angiography (CT-CA) and symptoms in diabetics and non-diabetics referred for cardiac evaluation. METHODS We followed 210 patients with diabetes type 2 (DM) and 203 non-diabetic patients referred for CT-CA for ruling out coronary artery disease (CAD). Patients were without known history of CAD and were divided into...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): State Research for Turku University Hospital. Background Combined anatomical and functional imaging enables detection non-obstructive obstructive coronary artery disease (CAD) as well myocardial ischemia, also provides prognostic information. Purpose We evaluated sex differences in...

OBJECTIVES We conducted a pilot study for a large definitive clinical trial evaluating the impact of ranolazine in women with angina, evidence of myocardial ischemia, and no obstructive coronary artery disease (CAD). BACKGROUND Women with angina, evidence of myocardial ischemia, but no obstructive CAD frequently have microvascular coronary dysfunction. The impact of ranolazine in this patient...

AIMS To evaluate the practical use of the single slice measurement of epicardial adipose tissue (EAT) at the level of the left main coronary artery (EATLM) in predicting the presence of obstructive coronary artery disease (CAD). METHODS AND RESULTS Quantification of EATTotal and EATLM was performed on non-contrast CT scans of consecutive patients (without history of revascularization, cardiac...

UNLABELLED In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive epicardial coronary artery disease (CAD), thereby presenting a diagnostic problem. We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis. METHODS Prospectively, 130 asymptomatic patients with di...

BACKGROUND Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population. METHODS We evaluated the association between MetS and CAD using the parameters including any...

Background: Patients with myocardial scar (scar) are at increased risk for cardiovascularmortality andmorbidity. Delayed enhancement cardiac magnetic resonance imaging (DE-CMR) is highly accurate in the detection of scar. The pattern ofmyocardial scar can be divided into 2 groups: 1. Coronary artery disease (CAD) based on location, ie extending from subendocardium to subepicardium; and 2. Non-C...

BACKGROUND Imaging stress tests are not ideally accurate to predict anatomically obstructive CAD, leading to a non-trivial rate of unnecessary iCA. This may depend on the threshold used to indicate iCA, and maybe CTA or, one step earlier, CT calcium score could spare most unnecessary iCA in only mildly positive cSE. We assessed the diagnostic accuracy of contrast stress-echocardiography (cSE) i...