nvp bez235

نتایج جستجو برای: nvp bez235

تعداد نتایج: 1391 فیلتر نتایج به سال:

Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models

Journal: :Transplant Immunology 2015

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Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy

Journal: :International Journal of Molecular Medicine 2013

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Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235

Journal: :Oncology Letters 2016

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Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012

Giorgia Migliardi Francesco Sassi Davide Torti Francesco Galimi Eugenia R Zanella Michela Buscarino Dario Ribero Andrea Muratore Paolo Massucco Alberto Pisacane Mauro Risio Lorenzo Capussotti Silvia Marsoni Federica Di Nicolantonio Alberto Bardelli Paolo M Comoglio Livio Trusolino Andrea Bertotti

PURPOSE Gene mutations along the Ras pathway (KRAS, NRAS, BRAF, PIK3CA) occur in approximately 50% of colorectal cancers (CRC) and correlate with poor response to anti-EGF receptor (EGFR) therapies. We assessed the effects of mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase (MEK) and phosphoinositide 3-kinase (PI3K)/mTOR inhibitors, which neutralize the major R...

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Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [F]FLT uptake Running Title [F]FLT uptake correlates with BEZ235 activity

2011

Thorsten Fuereder Thomas Wanek Pamina Pflegerl Agnes Jaeger-Lansky Doris Hoeflmayer Sabine Strommer Claudia Kuntner Friedrich Wrba Johannes Werzowa Michael Hejna Markus Müller Oliver Langer Volker Wacheck

Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Activation of the PI3K/mTOR pathway is a common event in gastric cancer and correlates with poor prognosis. PI3K/mTOR inhibition by the dual kinase inhibitor BEZ235 provides a novel and promising strategy for more effective treatment of gastric cancer patients. BEZ235 was recently reported to b...

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